THE CELLULAR AND MOLECULAR REGULATION OF 1,25(OH)2D(3) PRODUCTION

被引：29

作者：

HENRY, HL

DUTTA, C

CUNNINGHAM, N

BLANCHARD, R

PENNY, R

TANG, CL

MARCHETTO, G

CHOU, SY

机构：

[1] Department of Biochemistry, University of California, Riverside

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 1992年 / 41卷 / 3-8期

关键词：

D O I：

10.1016/0960-0760(92)90365-P

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of 1,25(OH)2D3 is a critical control point in the regulation of calcium metabolism, and possibly in the growth and differentiation of a number of cell types. This paper reviews our current understanding of the regulation of this process at the cellular and molecular levels, with the emphasis on the mechanisms of feedback control 1,25(OH)2D3 itself, control of parathyroid hormone, the roles of cyclic AMP dependent protein kinase and protein kinase C, and the interaction between the various intracellular regulators of 1,25(OH)2D3 production.

引用

页码：401 / 407

页数：7

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