HPV Cervical Infection and Immunodysregulation: Synergistic Risks for Neoplasia-Review

被引：0

作者：

Dhar, J. Patricia ^{[1
,2
]}

Lancaster, Wayne ^{[3
]}

Gregoire, Lucie ^{[4
,5
]}

Sokol, Robert J. ^{[6
]}

机构：

[1] Wayne State Univ, Univ Hlth Ctr, Sch Med, Internal Med & Obstet & Gynecol,Div Rheumatol, 4H-32,4201 St Antoine, Detroit, MI 48201 USA

[2] Wayne State Univ, Univ Hlth Ctr, Div Translat Res & Clin Epidemiol, Sch Med,Internal Med & Obstet & Gynecol, Detroit, MI 48201 USA

[3] Wayne State Univ, Sch Med, Ctr Mol Med & Genet, Detroit, MI USA

[4] Wayne State Univ, Sch Med, Immunol & Microbiol, Detroit, MI USA

[5] Wayne State Univ, Sch Med, Ctr Mol Med & Genet, Detroit, MI USA

[6] Wayne State Univ, Sch Med, CS Mott Ctr Human Growth & Dev Distinguished Obst, Detroit, MI 48201 USA

来源：

CURRENT WOMENS HEALTH REVIEWS | 2010年 / 6卷 / 04期

关键词：

Cervical cancer; human papillomavirus; systemic lupus erythematosus; lupus; cancer; cervical neoplasia;

D O I：

10.2174/157340410793362122

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

This review focuses on the genetics of human papilloma virus and immune dysregulation in cervical neoplasia. HPV, the putative agent in cervical cancer, is the most prevalent sexually transmitted infection worldwide. Cervical cancer is the second most common malignancy in women globally as well. Cervical neoplasia is increased in immuno-suppressed states, such as systemic lupus erythematosus. HPV has evolved mechanisms to evade the host immune system which are discussed. Malignant transformation from involves three steps: infection of the cervix, viral persistence, and progression to cancer. This process involves activation of viral oncogenes and integration of viral DNA into host genome. Cancer prevention and Screening strategies involve a combination of cervical cytology, high risk HPV testing, and colposcopy. Vaccination is effective in preventing primary HPV infection with the high risk HPV types causing the majority of cervical cancers. Experimental therapeutic vaccines offer new ways to treat cervical neoplasia.

引用

页码：287 / 296

页数：10

共 144 条

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