THE INFLUENCE OF ISOFLURANE ON THE SYNAPTIC ACTIVITY OF 5-HYDROXYTRYPTAMINE

被引：19

作者：

MARTIN, DC

ADAMS, RJ

ARONSTAM, RS

机构：

[1] MED COLL GEORGIA,DEPT PHYSIOL & ENDOCRINOL,AUGUSTA,GA 30912

[2] MED COLL GEORGIA,DEPT PHARMACOL & TOXICOL,AUGUSTA,GA 30912

来源：

NEUROCHEMICAL RESEARCH | 1990年 / 15卷 / 10期

关键词：

ANESTHETICS; BRAIN; BRAIN NEUROTRANSMITTERS; 5-HYDROXYTRYPTAMINE; ISOFLURANE; SEROTONIN;

D O I：

10.1007/BF00965741

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of isoflurane on uptake of 5-hydroxytryptamine (serotonin; 5-HT) by rat brain synaptosomes and binding of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and ketanserin to 5-HT1A and 5-HT2 receptors were examined. Isoflurane caused a concentration-dependent decrease in synaptosomal 5-HT uptake that was kinetically defined as non-competitive; exposure to isoflurane decreased V(max) but had no effect on the apparent K(m). Removal of the drug from the reaction mixture resulted in the return of 5-HT accumulation rates to control levels. Isoflurane inhibited 8-OH-DPAT binding to hippocampal membranes by up to 27 +/-6% at 4.5 mM, but not significantly affect ketanserin binding to 5-HT2 receptors. These findings suggest that presynaptic actions are more important than postsynaptic actions in the modulation of serotonergic neutrotransmission by isoflurane.

引用

页码：969 / 973

页数：5

共 17 条

[1]

ADAMS RJ, 1989, FASEB J, V31, pA1019

[2]

ALTHAUS JS, 1985, ANESTH ANALG, V64, P1163

[3] ACUTE AND CHRONIC TREATMENT WITH SELECTIVE SEROTONIN UPTAKE INHIBITORS IN MICE - EFFECTS ON NOCICEPTIVE SENSITIVITY AND RESPONSE TO 5-METHOXY-N,N-DIMETHYLTRYPTAMINE [J].