ACUTE MYELOMONOCYTIC LEUKEMIA WITH BONE-MARROW EOSINOPHILIA AND INV(16)(P13Q22),T(1-16)(Q32-Q22)

被引：20

作者：

YIP, MY ^{[1
]}

SHARMA, P ^{[1
]}

WHITE, L ^{[1
]}

机构：

[1] PRINCE WALES CHILDRENS HOSP, DEPT HAEMATOL ONCOL, SYDNEY, AUSTRALIA

来源：

CANCER GENETICS AND CYTOGENETICS | 1991年 / 51卷 / 02期

关键词：

D O I：

10.1016/0165-4608(91)90136-I

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A two-year-old girl presenting with de novo acute myelomonocytic leukemia with eosinophilia (French-American-British [FAB] classification, M4Eo) and inv(16)(p13q22), t(1;16)(q32;q22) involving the same chromosome 16 is described. This is the second report of a variant translocation of an inverted chromosome 16 with chromosome 1 at 1q32. However, the segment 1q32 --> 1qter has been exchanged for 16q22 --> qter and not 16p13 --> pter, as reported in the previous case. The additional break at 1q32 and the juxtaposition of 1q32 --> qter onto chromosome 16 could be relevant to the pathogenesis of the disease.

引用

页码：235 / 238

页数：4

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