2-DICHLOROMETHYL-NAPHTHIMIDAZOLE QUINONES .4. HETEROCYCLIC 1,4-NAPHTHOQUINONE DERIVATIVES

被引：0

作者：

KALLMAYER, HJ

BINGER, M

机构：

来源：

PHARMAZIE | 1991年 / 46卷 / 04期

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D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

2-Arylamino-3-dichloroacetylamino-1,4-naphthoquinones 4 show in ethanolic hydrochloric acid the same reactivity as the corresponding 3-monochloroacetylamino-1,4-naphthoquinone 3. After cyclisation from 4 to 6, 6 dehydrates to give 2-dichloromethyl-4,9-dihydro-1-phenyl-1H-naphth-[2,3-d-]imidazole-4,9-diones 8. Elimination of dichloromethane from 6 to 9 is not observed. The reaction of 4c in alkaline DMSO solution indicates, that ring closure to 3-hydroxy-benzo[g]quinoxalinetriones 2 is possible. The microbiological activity from 7 and 8 has been proved.

引用

页码：247 / 249

页数：3

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[2]

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[5]

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