Endocrine resistance in breast cancer From cellular signaling pathways to epigenetic mechanisms

被引：27

作者：

Bianco, Stephanie ^{[1
]}

Gevry, Nicolas ^{[1
]}

机构：

[1] Univ Sherbrooke, Fac Sci, Dept Biol, Sherbrooke, PQ, Canada

来源：

TRANSCRIPTION-AUSTIN | 2012年 / 3卷 / 04期

关键词：

endocrine resistance; breast cancer; transcription factor; epigenetic; genomic; chromatin;

D O I：

10.4161/trns.20496

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Although multiple cellular mechanisms have been proposed to explain endocrine resistance in breast cancer, the genomics events promoting the dys-regulation of gene expression pattern are not clearly understood. Because chromatin plays a dynamic role in the estrogen receptor alpha (ER alpha) transcriptional program, we herein review signaling pathways implicated in endocrine resistance and try to merge them with recent epigenetic studies.

引用

页码：165 / 170

页数：6

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