THE ROLE OF CYTOKINES IN INFLAMMATORY BOWEL-DISEASE

被引：7
作者：
RADFORDSMITH, G
JEWELL, DP
机构：
[1] Gastroenterology Unit, Radcliffe Infirmary, Oxford
来源：
MEDIATORS OF INFLAMMATION | 1994年 / 3卷 / 01期
关键词：
ULCERATIVE COLITIS (UC); CROHNS DISEASE (CD); CYTOKINES;
D O I：
10.1155/S0962935194000013
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
CYTOKINES play an important role in the development and persistence of the inflammatory lesions seen in Crohn's disease and ulcerative colitis. This review discusses the current thinking of the role of cytokines in chronic intestinal inflammation including the involvement of immunoregulatory cytokines within the Th1 and Th2 subsets.
引用
收藏
页码：3 / 9
页数：7
相关论文
共 81 条
[1]  
ARYA SK, 1984, J IMMUNOL, V133, P273
[2]   THE CYTOKINE NETWORK [J].
BALKWILL, FR ;
BURKE, F .
IMMUNOLOGY TODAY, 1989, 10 (09) :299-303
[3]   IDENTIFICATION OF AN INDUCIBLE ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE [J].
BEVILACQUA, MP ;
POBER, JS ;
MENDRICK, DL ;
COTRAN, RS ;
GIMBRONE, MA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (24) :9238-9242
[4]   INCREASED CONCENTRATIONS OF INTERLEUKIN 1-BETA, INTERLEUKIN-2, AND SOLUBLE INTERLEUKIN-2 RECEPTORS IN ENDOSCOPIC MUCOSAL BIOPSY SPECIMENS WITH ACTIVE INFLAMMATORY BOWEL-DISEASE [J].
BRYNSKOV, J ;
TVEDE, N ;
ANDERSEN, CB ;
VILIEN, M .
GUT, 1992, 33 (01) :55-58
[5]  
CACERESDITTMAR G, 1993, CLIN EXP IMMUNOL, V91, P500, DOI 10.1111/j.1365-2249.1993.tb05931.x
[6]   DIFFERENCES IN THE EXPRESSION AND RELEASE OF DR, BR, AND DQ MOLECULES IN HUMAN-CELLS TREATED WITH RECOMBINANT INTERFERON GAMMA - COMPARISON TO OTHER INTERFERONS [J].
CAPOBIANCHI, MR ;
AMEGLIO, F ;
TOSI, R ;
DOLEI, A .
HUMAN IMMUNOLOGY, 1985, 13 (01) :1-11
[7]   DETECTION OF MESSENGER-RNAS FOR MACROPHAGE PRODUCTS IN INFLAMMATORY BOWEL-DISEASE BY INSITU HYBRIDIZATION [J].
CAPPELLO, M ;
KESHAV, S ;
PRINCE, C ;
JEWELL, DP ;
GORDON, S .
GUT, 1992, 33 (09) :1214-1219
[8]   DIFFERENTIAL EXPRESSION OF CD25 (INTERLEUKIN-2 RECEPTOR) ON LAMINA PROPRIA T-CELLS AND MACROPHAGES IN THE INTESTINAL LESIONS IN CROHNS-DISEASE AND ULCERATIVE-COLITIS [J].
CHOY, MY ;
WALKERSMITH, JA ;
WILLIAMS, CB ;
MACDONALD, TT .
GUT, 1990, 31 (12) :1365-1370
[9]   THE HUMAN HEMATOPOIETIC COLONY-STIMULATING FACTORS [J].
CLARK, SC ;
KAMEN, R .
SCIENCE, 1987, 236 (4806) :1229-1237
[10]   MULTIPLE DEFECTS OF IMMUNE CELL-FUNCTION IN MICE WITH DISRUPTED INTERFERON-GAMMA GENES [J].
DALTON, DK ;
PITTSMEEK, S ;
KESHAV, S ;
FIGARI, IS ;
BRADLEY, A ;
STEWART, TA .
SCIENCE, 1993, 259 (5102) :1739-1742
123456789