CHRONIC LITHIUM ADMINISTRATION ENHANCES AMPHETAMINE-INDUCED NOREPINEPHRINE INCREASE IN THE PARAVENTRICULAR NUCLEUS OF THE HYPOTHALAMUS IN RATS - AN IN-VIVO MICRODIALYSIS STUDY

被引：3

作者：

BAPTISTA, T

TENEUD, L

CONTRERAS, Q

ALASTRE, T

BURGUERA, JL

DEBURGUERA, M

HERNANDEZ, L

机构：

[1] UNIV LOS ANDES,SCH MED,DEPT PHYSIOL,MERIDA,VENEZUELA

[2] UNIV LOS ANDES,SCH MED,DEPT PSYCHIAT,MERIDA,VENEZUELA

[3] UNIV LOS ANDES,SCH CHEM,MOLEC SPECT LAB,MERIDA,VENEZUELA

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 1995年 / 19卷 / 02期

关键词：

LITHIUM; NOREPINEPHRINE; PARAVENTRICULAR HYPOTHALAMUS; RATS; MICRODIALYSIS;

D O I：

10.1016/0278-5846(95)00008-J

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

1. Previous reports have shown that lithium (Li) decreases noradrenergic (NE) transmission in rat cortex and striatum. Since Li is widely used to treat mood disorders, and can also modulate food intake in both humans and rats, the authors investigated its effects on hypothalamic norepinephrine. 2. The authors used a microdialysis procedure to measure NE in the paraventricular nucleus of the hypothalamus of rats. 3. Basal levels of NE were not affected by Li (2 mEq/kg/intragastrically for 14 days); however the increase in NE after amphetamine (12 mu g through probe) was significantly enhanced by Li.

引用

页码：273 / 279

页数：7