SYNTHESIS AND BIOLOGICAL-ACTIVITY OF BROMOLIGNANS AND CYCLOLIGNANS

被引：0

作者：

SANFELICIANO, A ^{[1
]}

MEDARDE, M ^{[1
]}

DECLAIRAC, RPL ^{[1
]}

LOPEZ, JL ^{[1
]}

PUEBLA, P ^{[1
]}

GRAVALOS, MDG ^{[1
]}

LAZARO, PR ^{[1
]}

DEQUESADA, MTG ^{[1
]}

机构：

[1] PHARMA MAR,E-28780 MADRID,SPAIN

来源：

ARCHIV DER PHARMAZIE | 1993年 / 326卷 / 07期

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中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Nine lignan derivatives (4-12) have been obtained from (-)-yatein by treatment with DDQ and NBS. They showed moderate antineoplastic activity (P-388, A-549, HT-29) compared with podophyllotoxin, but some of them have a better therapeutic index. None of the tested compounds shows antiviral (HSV-1, VSV) or enzyme inhibitor (ADA, DHFR, GST) activities.

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页码：421 / 426

页数：6

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