PREPARATION AND PERFORMANCE OF CHITOSAN ENCAPSULATED ACTIVATED-CHARCOAL (ACCB) ADSORBENTS FOR SMALL MOLECULES

被引：15

作者：

CHANDY, T ^{[1
]}

SHARMA, CP ^{[1
]}

机构：

[1] SREE CHITRA TIRUNAL INST MED SCI & TECHNOL,DIV BIOSURFACE TECHNOL,BMT WING,TRIVANDRUM 695012,INDIA

来源：

JOURNAL OF MICROENCAPSULATION | 1993年 / 10卷 / 04期

关键词：

D O I：

10.3109/02652049309015324

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A technique is described to encapsulate activated charcoal for haemoperfusion to be used in an artificial liver support. Activated charcoal was encapsulated within chitosan matrix (ACCB) in different concentrations, and was used as the supports for perfusion of a mixture of solutes, having molecular weight ranges from 60 to 69000; under a flow rate of 8 ml/min. It seems the ACCB may be a good adsorbent system for the removal of toxic uric acid, creatinine, bilirubin, etc., from solutions; while larger molecules such as albumin are adsorbed less. The encapsulated charcoal did not leach out from the matrix during perfusion, and the system may be useful for detoxification of blood. The haemolytic potential of ACCB has been compatible with polystyrene control tubes. However, further studies are needed to determine their behaviour under clinical conditions.

引用

页码：475 / 486

页数：12

共 22 条

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