SUSTAINED DRUG DELIVERY SYSTEMS .2. FACTORS AFFECTING RELEASE RATES FROM POLY(EPSILON-CAPROLACTONE) AND RELATED BIODEGRADABLE POLYESTERS

被引：168
作者：
PITT, CG
GRATZL, MM
JEFFCOAT, AR
ZWEIDINGER, R
SCHINDLER, A
机构：
[1] Research Triangle Institute, Research Triangle Park, North Carolina
来源：
JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 12期
关键词：
Drug delivery systems—kinetics; biodegradation; diffusion; films; capsules; Poly(ε‐caprolactone)—homopolymers; copolymers; release rates; Polyesters; biodegradable—poly(ε‐caprolactone); poly(DL‐lactic acid); steroid release; Sustained‐release systems—biodegradable polyesters; poly(ε‐caprolactone);
D O I：
10.1002/jps.2600681219
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The release rates of several steroids from films and capsules of homopolymers and copolymers of .epsilon.-caprolactone, DL-lactic acid and glycolic acid were measured in vitro and in vivo [in rabbits and rats] for up to 200 days. Relatively constant release rates from capsules (reservoir devices) were observed only under certain conditions. Factors that influence the drug release kinetics were evaluated. Release from poly(.epsilon.-caprolactone) and poly(.epsilon.-caprolactone-co-DL-lactic acid) was diffusion controlled. Release from poly(DL-lactic acid-co-glycolic acid) was associated with polymer degradation. Release from poly(DL-lactic acid) was very slow when diffusion controlled.
引用
收藏
页码：1534 / 1538
页数：5
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