RHEUMATOID SYNOVIAL LYMPHOCYTES LACK CONCANAVALIN-A-ACTIVATED SUPPRESSOR CELL-ACTIVITY

被引：71
作者：
CHATTOPADHYAY, C
CHATTOPADHYAY, H
NATVIG, JB
MELLBYE, OJ
机构：
[1] Institute of Immunology and Rheumatology, Rikshospitalet, The National Hospital, Oslo
来源：
SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 1979年 / 10卷 / 05期
关键词：
D O I：
10.1111/j.1365-3083.1979.tb01378.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Synovial lymphocytes eluted by enzyme treatment from eleven patients with rheumatoid arthritis (RA) were investigated for the presence of concanavalin A (Con A)‐activated suppressor cell activity as compared with that of peripheral blood lymphocytes of twenty normal donors. In addition, two patients with psoriatic arthritis and juvenile rheumatoid arthritis (JRA) were also investigated. Synovial lymphocytes from the eleven RA patients showed a mean augmentation of 28±13.30, and thus clearly lacked suppressor activity, whereas the mean suppression in the lymphocytes from the twenty normal donors was 13 ±14.40. Synovial lymphocytes from one patient with JRA and one with psoriatic arthritis showed a normal suppressor activity. Copyright © 1979, Wiley Blackwell. All rights reserved
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页码：479 / 486
页数：8
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