STRUCTURE-ACTIVITY-RELATIONSHIPS IN THE DEVELOPMENT OF EXCITATORY AMINO-ACID RECEPTOR AGONISTS AND COMPETITIVE ANTAGONISTS

被引：885

作者：

WATKINS, JC

KROGSGAARDLARSEN, P

HONORE, T

机构：

[1] ROYAL DANISH SCH PHARM, DEPT ORGAN CHEM, DK-2100 COPENHAGEN, DENMARK

[2] NOVONORDISK, CENT NERVOUS SYST UNIT, CENT NERVOUS SYST DISCOVERY, DK-2860 SOBORG, DENMARK

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 1990年 / 11卷 / 01期

关键词：

(+)-5-Methyl-10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate; (RS)-cis-4phosphono-methylpiperidine-2-carboxilic acid; (±)-N-allylnormetazocine; 1-[1-(2-thienyl)-cyclohexyl]piperidine; CGP19755; CGP37849; D; L-(E)-2-amino-4-methyl-5-phosphono-3-pentanoic acid; MK801; ODAP; PCP1; phencyclidine; SKF10047; TCP; β-N-oxalyl-αβ-diaminopropionic acid;

D O I：

10.1016/0165-6147(90)90038-A

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Development of new selective ligands for excitatory amino acid receptors has been fundamental in supporting this rapidly developing field. Some of the most important ligands have come from the laboratories of Jeff Watkins, Povl Krogsgaard-Larsen and Tage Honoré, who collaborate in this double-length review to describe the chemical features and SARs of agonists and antagonists, particularly those features associated with subtype selectivity. © 1990.

引用

页码：25 / 33

页数：9

共 68 条

[1] SYNTHESIS AND NMDA ANTAGONISTIC PROPERTIES OF THE ENANTIOMERS OF 4-(3-PHOSPHONOPROPYL)PIPERAZINE-2-CARBOXYLIC ACID (CPP) AND OF THE UNSATURATED ANALOG (E)-4-(3-PHOSPHONOPROP-2-ENYL)PIPERAZINE-2-CARBOXYLIC ACID (CPP-ENE) [J].