Showing the Way: Oncolytic Adenoviruses as Chaperones of Immunostimulatory Adjuncts

被引：9

作者：

Huang, Jing Li ^{[1
]}

LaRocca, Christopher J. ^{[1
]}

Yamamoto, Masato ^{[1
]}

机构：

[1] Univ Minnesota, Dept Surg, Minneapolis, MN 55455 USA

来源：

BIOMEDICINES | 2016年 / 4卷 / 03期

关键词：

oncolytic adenovirus; immunotherapy; oncolytic virotherapy; GM-CSF (granulocyte macrophage colony-stimulating factor); interferon-alpha; interferon-gamma; interleukin-12; CD40L; CTLA-4;

D O I：

10.3390/biomedicines4030023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Oncolytic adenoviruses (OAds) are increasingly recognized as vectors for immunotherapy in the treatment of various solid tumors. The myriads of advantages of using adenovirus include targeted specificity upon infection and selective replication, which lead to localized viral burst, exponential spread of OAds, and antitumor effect. OAds can also induce a strong immune reaction due to the massive release of tumor antigens upon cytolysis and the presence of viral antigens. This review will highlight recent advances in adenoviral vectors expressing immunostimulatory effectors, such as GM-CSF (granulocyte macrophage colony-stimulating factor), interferon-ff, interleukin-12, and CD40L. We will also discuss the combination of OAds with other immunotherapeutic strategies and describe the current understanding of how adenoviral vectors interact with the immune system to eliminate cancer cells.

引用

页数：14

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