PROTEINASE-INHIBITORS, KININS AND THE INFLAMMATORY REACTION INDUCED BY SPONGE IMPLANTATION IN RATS

被引：11

作者：

DAMAS, J ^{[1
]}

BOURDON, V ^{[1
]}

REMACLEVOLON, G ^{[1
]}

ADAM, A ^{[1
]}

机构：

[1] UNIV MONTREAL,FAC PHARM,MONTREAL H3C 3J7,QUEBEC,CANADA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 175卷 / 03期

关键词：

Inflammations; Kinins; Proteinase inhibitors; Sponge;

D O I：

10.1016/0014-2999(90)90573-O

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We studied the influence of aprotinin and soya bean trypsin inhibitor (SBTI) on the inflammatory reaction induced by the implantation of dry sponges in normal Wistar rats and in kininogen-deficient Brown Norway rats, during the first day after the implantation. In normal rats, aprotinin reduced the volume and total protein content of the exudates at 3 h but not thereafter. Aprotinin also markedly reduced the immunoreactive kinins and kallikrein in the exudates. Aprotinin did not modify the volume of the exudates of the Brown Norway rats. SBTI reduced the inflammatory reaction in both rat strains but did not significantly modify the formation of immunoreactive kinins. The inflammatory reaction developed more slowly in Brown Norway rats. The kinin system is thus involved during the first hours of the development of this acute inflammatory reaction. The anti-inflammatory effect of SBTI does not depend on the inhibition of kinin formation. © 1990.

引用

页码：341 / 346

页数：6

共 20 条

[1] QUANTIFICATION OF RAT T-KININOGEN USING IMMUNOLOGICAL METHODS - APPLICATION TO INFLAMMATORY PROCESSES [J].