SPECTROPHOTOMETRIC STUDIES OF INTERACTIONS BETWEEN VARIOUS SUBSTRATES IN THEIR BINDING TO MICROSOMAL CYTOCHROME P-450

被引：53
作者：
LEIBMAN, KC
HILDEBRANDT, AG
ESTABROOK, RW
机构：
[1] Department of Biochemistry, University of Texas Southwestern Medical School, Dallas
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1969年 / 36卷 / 05期
关键词：
D O I：
10.1016/0006-291X(69)90678-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The question of whether liver microsomes contain a single cytochrome P-450 with broad substrate specificity or a multitude of different cytochromes P-450 with high substrate specificity has been examined by determining the patterns of spectral changes in the presence of various combinations of substrates. The results can be explained in terms of the existence of two spectrally distinguishable forms of cytochrome P-450, which can associate with various substrates to form complexes which are spectrally similar to, but not necessarily identical to, one or the other of these forms. © 1969.
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页码：789 / +
页数：1
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