COMPLETE RESPONSE OF TRANSVERSE COLON-CARCINOMA TO S1, A NEW CHEMOTHERAPY AGENT - REPORT OF A CASE

被引：2
作者：
MIMORI, K
MORI, M
BABA, H
MAEHARA, Y
SUGIMACHI, K
机构：
[1] Department of Surgery, Medical Institute of Bioregulation, Kyushu University, Beppu, 874
[2] Second Department of Surgery, Kyushu University, Fukuoka, 812, 3-1-1 Maidashi, Higashi-ku
来源：
SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY | 1995年 / 25卷 / 08期
关键词：
S1; TRANSVERSE COLON CARCINOMA; CARCINOEMBRYONIC ANTIGEN; MUCIN POOL; COMPLETE RESPONSE;
D O I：
10.1007/BF00311492
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
A complete response to a new chemotherapeutic agent, S1, was achieved in a 64-year-old Japanese man with advanced transverse colon cancer. S1 is a combination of the agents tegafur, 5-chloro-2,4-dihydroxypyridine, and oxonic acid. Because the patient was considered to be a high operative risk due to his poor general condition, S1 was administered at 100 mg/day for 5 days/week over 12 weeks. However, as the serum carcinoembryonic antigen level continued to gradually increase, partial resection of the transverse colon was finally performed. Histopathological study of the resected specimen showed mucin pools in the colon wall with no residual viable cancer cells. No perioperative complications were recognized and the patient is now leading a normal life 6 months after his operation without any signs of recurrence.
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页码：741 / 744
页数：4
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  • [1] Tatsumi K., Fukushima M., Shirasaka T., Kimura K., Inhibitory effect of pyrimidine, barbituric acid and pyridine derivatives on 5-fluorouracil degeneration in rat liver extracts, Jpn J Cancer Res, 78, pp. 748-755, (1987)
  • [2] Shirasaka T., Shimamoto Y., Fukushima M., Inhibition by oxonic acid of gastrointestinal toxicity of 5-fluorouracil without loss of its antitumor activity in rats, Cancer Res, 53, pp. 4004-4009, (1993)
  • [3] Mayer R.J., Chemotherapy for metastatic colorectal cancer, Cancer, 70, pp. 1414-1424, (1992)
  • [4] Kemeny N., Lokich J.J., Anderson N., Ahlgren J.D., Recent advances in the treatment of advanced colorectal cancer, Cancer, 71, pp. 9-18, (1993)
  • [5] Rustum Y.M., Trave F., Zakrzewski S.F., Petrelli N., Herrera L., Mittelman A., Biochemical and pharmacologic basis for potentiation of 5-fluorouracil action by leucovorin, NCI Monogr, 5, pp. 165-170, (1987)
  • [6] Mini E., Mazzei T., Coronnello M., Criscuoli L., Gualtieri M., Periti P., Effects of 5-methyltetra-hydrofolate on the activity of fluoro pyrimidines against human leukemia (CCRF-CEM) cells, Biochem Pharmacol, 36, pp. 2905-2911, (1987)
  • [7] Houghton J.A., Houghton P.J., Wooten R.S., Mechanism of induction of gastrointestinal toxicity in the mouse by 5-fluorouracil, 5-fluorouridine and 5-fluoro-2′-deoxyuridine, Cancer Res, 39, pp. 2406-2413, (1979)
  • [8] Shuetz J.D., Wallace H.J., Diasio R.B., 5-fluorouracil incorporation into DNA of CF-1 mouse bone marrow cells as a possible mechanism of toxicity, Cancer Res, 44, pp. 1358-1363, (1984)
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