MODELING OF PEPTIDE AND PROTEIN STRUCTURES

被引：4
|
作者：
FRAGA, S
PARKER, JMR
机构：
[1] UNIV ALBERTA, ALBERTA PEPTIDE INST, EDMONTON T6G 2G2, AB, CANADA
[2] UNIV ALBERTA, DEPT BIOCHEM, EDMONTON T6G 2G2, AB, CANADA
来源：
AMINO ACIDS | 1994年 / 7卷 / 02期
关键词：
AMINO ACIDS; PEPTIDES; PROTEINS; MODELING; SIMULATIONS;
D O I：
10.1007/BF00814159
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The modelling of protein structures (whether isolated, in solution, or involved in recognition processes) is reviewed, free of any mathematical apparatus, to provide an overview of the concepts as well as leading references. A general feeling for this field of work is first established by a sampling of some impressions on its difficulties and chances of success. Then, the main body of this work examines the information available (databases and parameters), presents the theoretical foundations for the modelling procedures (with emphasis on the potential energy functions), surveys the existing simulation techniques and prediction methods, and discusses the problems still to be faced. For completeness, a representative list of existing software packages is presented in the Appendix.
引用
收藏
页码：175 / 202
页数：28
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