RECURVOSIDES-A-E, NEW POLYHYDROXYLATED STEROIDAL SAPONINS FROM NOLINA-RECURVATA STEMS

被引：25
作者：
TAKAASHI, Y
MIMAKI, Y
KURODA, M
SASHIDA, Y
NIKAIDO, T
OHMOTO, T
机构：
[1] TOKYO UNIV PHARM & LIFE SCI,SCH PHARM,HACHIOJI,TOKYO 19203,JAPAN
[2] TOHO UNIV,SCH PHARMACEUT SCI,FUNABASHI,CHIBA 274,JAPAN
来源：
TETRAHEDRON | 1995年 / 51卷 / 08期
关键词：
D O I：
10.1016/0040-4020(94)01098-K
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of five new polyhydroxylated steroidal saponins, named recurvosides A - E, were isolated from the stems of Nolina recurvata (Agavaceae). Their structures were determined through detailed interpretation of various spectra, including two-dimensional (2D) NMR, and by acid-catalized hydrolysis. Among them, recurvoside E was revealed to be very unique in structure being a trisdesmoside with a beta-D-fructofuranose as the monosaccharide component attached to the C-21 hydroxyl group of the aglycone. The isolated saponins were evaluated for inhibitory activity on cAMP phosphodiesterase as a primary screening test to find new biologically active compounds.
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收藏
页码：2281 / 2292
页数：12
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