TUMOR-NECROSIS-FACTOR-ALPHA INCREASES THE UBIQUITINIZATION OF RAT SKELETAL-MUSCLE PROTEINS

被引：119
作者：
GARCIAMARTINEZ, C
AGELL, N
LLOVERA, M
LOPEZSORIANO, FJ
ARGILES, JM
机构：
[1] UNIV BARCELONA, FAC MED, DEPT BIOL CELULAR, BARCELONA 7, SPAIN
[2] UNIV BARCELONA, FAC BIOL, DEPT BIOQUIM & FISIOL, BARCELONA 7, SPAIN
来源：
FEBS LETTERS | 1993年 / 323卷 / 03期
关键词：
TNF; PROTEIN METABOLISM; UBIQUITIN; CACHEXIA;
D O I：
10.1016/0014-5793(93)81341-V
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
An acute intravenous administration of 100 mug/kg body weight of recombinant tumour necrosis factor-alpha (TNF) resulted in a time-dependent increase in the levels of both free and conjugated ubiquitin in rat skeletal muscle. The effects of the cytokine were more pronounced in the red muscle soleus than in the white muscle EDL. In the former muscle type, TNF-treatment also resulted in a time-dependent increase in the percentage of free ubiquitin. The results suggest that the ubiquitin system for non-lysosomal protein degradation could have a very important role in the mechanism triggered by TNF which is responsible for enhanced muscle proteolysis in sepsis and other pathological states.
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收藏
页码：211 / 214
页数：4
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