THE PLASMA HALOPERIDOL AND REDUCED HALOPERIDOL CONCENTRATIONS IN CHINESE SCHIZOPHRENIC-PATIENTS - RELATIONSHIP BETWEEN REDUCED HALOPERIDOL HALOPERIDOL RATIO AND RED-BLOOD-CELL HALOPERIDOL REDUCTASE-ACTIVITY

Fifteen chinese schizophrenic patients were given titrated doses of haloperidol (0.05-0.42 mg/kg) for two weeks. All these 15 patients were in clinical remission on maintenance dose of haloperidol. The mean plasma haloperidol and reduced haloperidol concentrations were 16.8 +/- 4.8 ng/ml and 13.6 +/- 5.7 ng/ml respectively. The plasma RHAL/HAL ratio was in the range of 0.13-1.94. These valueS were similar to that reported for the Japanese population. The frequency distribution appeared to be bimodal. RBC reductase activity were found to be distributed normally and no correlation was found between plasma RHAL/HAL ratio and RBC reductase activity.