PRIMARY STRUCTURE AND EXPRESSION OF THE GAMMA-2 SUBUNIT OF THE GLUTAMATE RECEPTOR CHANNEL SELECTIVE FOR KAINATE

被引：162
作者：
SAKIMURA, K
MORITA, T
KUSHIYA, E
MISHINA, M
机构：
[1] Department of Neuropharmacology Brain Research Institute Niigata University Niigata
来源：
NEURON | 1992年 / 8卷 / 02期
关键词：
D O I：
10.1016/0896-6273(92)90293-M
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The presence and primary structure of a novel subunit of the mouse glutamate receptor channel, designated as gamma-2, have been revealed by cloning and sequencing the CDNA. The gamma-2 subunit has structural characteristics common to the neurotransmitter-gated ion channel family and shares a high amino acid sequence identity with the rat KA-1 subunit, thus constituting the gamma-subfamily of the glutamate receptor channel. Expression of the gamma-2 subunit together with the beta-2 subunit in Xenopus oocytes yields functional glutamate receptor channels selective for kainate.
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页码：267 / 274
页数：8
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