RNA polymerase II conserved protein domains as platforms for protein-protein interactions

被引：8

作者：

Carmen Garcia-Lopez, M. ^{[1
]}

Navarro, Francisco ^{[1
]}

机构：

[1] Univ Jaen, Fac Ciencias Expt, Dept Biol Expt, Jaen, Spain

来源：

TRANSCRIPTION-AUSTIN | 2011年 / 2卷 / 04期

关键词：

RNA polymerases; structure; transcription factors; protein-protein interactions; eukaryotic;

D O I：

10.4161/trns.2.4.16786

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

RNA polymerase II establishes many protein-protein interactions with transcriptional regulators to coordinate gene expression, but little is known about protein domains involved in the contact with them. We use a new approach to look for conserved regions of the RNA pol II of S. cerevisiae located at the surface of the structure of the complex, hypothesizing that they might be involved in the interaction with transcriptional regulators. We defined five different conserved domains and demonstrate that all of them make contact with transcriptional regulators.

引用

页码：193 / 197

页数：5

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