HIV treatment is associated with a twofold higher probability of raised triglycerides: pooled analyses in 21 023 individuals in sub-Saharan Africa

被引：11

作者：

Ekoru, K. ^{[1
,2
]}

Young, E. H. ^{[1
,2
]}

Dillon, D. G. ^{[3
]}

Gurdasani, D. ^{[1
,2
]}

Stehouwer, N. ^{[4
]}

Faurholt-Jepsen, D. ^{[5
]}

Levitt, N. S. ^{[6
]}

Crowther, N. J. ^{[7
]}

Nyirenda, M. ^{[8
]}

Njelekela, M. A. ^{[9
]}

Ramaiya, K. ^{[10
]}

Nyan, O. ^{[11
]}

Adewole, O. O. ^{[12
]}

Anastos, K. ^{[13
]}

Compostella, C. ^{[14
]}

Dave, J. A. ^{[15
]}

Fourie, C. M. ^{[16
]}

Friis, H. ^{[17
]}

Kruger, I. M. ^{[18
]}

Longenecker, C. T. ^{[4
]}

Maher, D. P. ^{[19
]}

Mutimura, E. ^{[13
]}

Ndhlovu, C. E. ^{[20
]}

Praygod, G. ^{[21
]}

Yone, E. W. Pefura ^{[22
]}

Pujades-Rodriguez, M. ^{[23
,24
]}

Range, N. ^{[21
]}

Sani, M. U. ^{[25
]}

Sanusi, M. ^{[25
]}

Schutte, A. E. ^{[16
,26
]}

Sliwa, K. ^{[27
]}

Tien, P. C. ^{[28
]}

Vorster, E. H. ^{[29
]}

Walsh, C. ^{[30
]}

Gareta, D. ^{[31
]}

Mashili, F. ^{[21
]}

Sobngwi, E. ^{[32
]}

Adebamowo, C. ^{[33
,34
,35
]}

Kamali, A. ^{[36
]}

Seeley, J. ^{[36
]}

Smeeth, L. ^{[37
]}

Pillay, D. ^{[31
]}

Motala, A. A. ^{[38
]}

Kaleebu, P. ^{[36
]}

Sandhu, M. S. ^{[1
,2
]}

机构：

[1] Univ Cambridge, Dept Med, Cambridge, England

[2] Wellcome Trust Sanger Inst, Global Hlth & Populat Grp, Cambridge, England

[3] Weill Cornell Med Coll, New York, NY USA

[4] Univ Hosp Case Med Ctr, Cleveland, OH USA

[5] Univ Copenhagen, Rigshosp, Dept Infect Dis, Copenhagen, Denmark

[6] Univ Cape Town, Dept Med, Div Diabet Med & Endocrinol, Cape Town, South Africa

[7] Univ Witwatersrand, Med Sch, Natl Hlth Lab Serv, Dept Chem Pathol, Johannesburg, South Africa

[8] Malawi Epidemiol & Intervent Res Unit, Lilongwe, Malawi

[9] Muhimbili Univ Hlth & Allied Sci, Dept Physiol, Dar Es Salaam, Tanzania

[10] Shree Hindu Mandal Hosp, Dar Es Salaam, Tanzania

[11] Univ Gambia, Sch Med, Royal Victoria Teaching Hosp, Banjul, Gambia

[12] Obafemi Awolowo Univ, Dept Med, Ife, Nigeria

[13] Albert Einstein Coll Med, Bronx, NY 10467 USA

[14] Univ Padua, Dept Med, Padua, Italy

[15] Univ Cape Town, Dept Med, Div Diabet Med & Endocrinol, Cape Town, South Africa

[16] North West Univ, HART, Potchefstroom, South Africa

[17] Univ Copenhagen, Fac Sci, Dept Nutr Exercise & Sports, Copenhagen, Denmark

[18] North West Univ, Africa Unit Transdisciplinary Hlth Res AUTHeR, Potchefstroom, South Africa

[19] WHO, Special Programme Res & Training Trop Dis TDR, Geneva, Switzerland

[20] Univ Zimbabwe, Coll Hlth Sci, Clin Epidemiol Resource Training Ctr, Harare, Zimbabwe

[21] Natl Inst Med Res, Dar Es Salaam, Tanzania

[22] Yaounde Jamot Hosp, Chest Unit, Yaounde, Cameroon

[23] Med Sans Frontieres, Epictr, Paris, France

[24] UCL, Clin Epidemiol Grp, Dept Epidemiol & Publ Hlth, London, England

[25] Aminu Kano Teaching Hosp, Dept Med, Cardiol Unit, Kano, Nigeria

[26] North West Univ, MRC Unit Hypertens & Cardiovasc Dis, Potchefstroom, South Africa

[27] Univ Witwatersrand, Chris Hani Baragwanath Hosp, Soweto Cardiovasc Res Unit, Johannesburg, South Africa

[28] Univ Calif San Francisco, Dept Med, San Francisco, CA USA

[29] North West Univ, Fac Hlth Sci, Potchefstroom, South Africa

[30] Univ Free State, Dept Nutr & Dietet, Bloemfontein, South Africa

[31] Univ KwaZulu Natal, Africa Hlth Res Inst, Durban, South Africa

[32] Univ Yaounde I, Fac Med & Biomed Sci, Yaounde, Cameroon

[33] Inst Human Virol, Abuja, Nigeria

[34] Univ Maryland, Sch Med, Inst Human Virol, Dept Epidemiol & Publ Hlth, Baltimore, MD 21201 USA

[35] Univ Maryland, Sch Med, Greenebaum Canc Ctr, Baltimore, MD 21201 USA

[36] MRC UVRI Uganda Res Unit AIDS, Entebbe, Uganda

[37] London Sch Hyg & Trop Med, Fac Epidemiol & Populat Hlth, London, England

[38] Univ KwaZulu Natal, Nelson R Mandela Sch Med, Dept Endocrinol & Diabet, Durban, South Africa

来源：

GLOBAL HEALTH EPIDEMIOLOGY AND GENOMICS | 2018年 / 3卷

基金：

英国医学研究理事会;

关键词：

Antiretroviral therapy; cardiovascular disease; HIV; lipids; sub-Saharan Africa; triglycerides;

D O I：

10.1017/gheg.2018.7

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Background Anti-retroviral therapy (ART) regimes for HIV are associated with raised levels of circulating triglycerides (TGs) in western populations. However, there are limited data on the impact of ART on cardiometabolic risk in sub-Saharan African (SSA) populations. Methods Pooled analyses of 14 studies comprising 21 023 individuals, on whom relevant cardiometabolic risk factors (including TG), HIV and ART status were assessed between 2003 and 2014, in SSA. The association between ART and raised TG (>2.3 mmol/L) was analysed using regression models. Findings Among 10 615 individuals, ART was associated with a two-fold higher probability of raised TG (RR 2.05, 95% CI 1.51-2.77, I2 = 45.2%). The associations between ART and raised blood pressure, glucose, HbA1c, and other lipids were inconsistent across studies. Interpretation Evidence from this study confirms the association of ART with raised TG in SSA populations. Given the possible causal effect of raised TG on cardiovascular disease (CVD), the evidence highlights the need for prospective studies to clarify the impact of long term ART on CVD outcomes in SSA.

引用

页数：13

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