Nonimmunity against hepatitis B virus infection in patients newly diagnosed with inflammatory bowel disease

被引：8

作者：

Yeo, Seong Jae ^{[1
]}

Lee, Hyun Seok ^{[1
]}

Jang, Byung Ik ^{[2
]}

Kim, Eun Soo ^{[1
]}

Jeon, Seong Woo ^{[1
]}

Kim, Sung Kook ^{[1
]}

Kim, Kyeong Ok ^{[2
]}

Lee, Yoo Jin ^{[3
]}

Lee, Hyun Jik ^{[3
]}

Park, Kyung Sik ^{[3
]}

Jung, Yun Jin ^{[4
]}

Kim, Eun Young ^{[5
]}

Yang, Chang Heon ^{[6
]}

机构：

[1] Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, 807 Hoguk Ro, Daegu 41404, South Korea

[2] Yeungnam Univ, Coll Med, Dept Internal Med, Daegu, South Korea

[3] Keimyung Univ, Sch Med, Dept Internal Med, Daegu, South Korea

[4] Daegu Fatima Hosp, Dept Internal Med, Daegu, South Korea

[5] Cathol Univ Daegu, Sch Med, Dept Internal Med, Daegu, South Korea

[6] Dongguk Univ, Sch Med, Dept Internal Med, Gyeongju, South Korea

来源：

INTESTINAL RESEARCH | 2018年 / 16卷 / 03期

关键词：

Inflammatory bowel disease; Colitis; ulcerative; Crohn disease; Hepatitis B virus; Vaccination;

D O I：

10.5217/ir.2018.16.3.400

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background/Aims: This study aimed to elucidate the prevalence of hepatitis B virus (HBV) serologic markers in Korean patients newly diagnosed with, but not yet treated for inflammatory bowel disease (IBD). Methods: We prospectively enrolled 210 patients newly diagnosed with IBD (109 with ulcerative colitis and 101 with Crohn's disease). Hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (anti-HBs), and hepatitis B core antibody (anti-HBc) levels were measured and compared with those of 1,100 sex-and age-matched controls. Results: The prevalence of chronic HBV infection (positive HBsAg, positive anti-HBc, and negative anti-HBs results) and past infection (negative HBsAg, positive anti-HBc, and positive or negative anti-HBs results) were not significantly different between the patients and controls (chronic HBV infection: IBD, 3.8% vs. control, 4.9%, P=0.596; past infection: IBD, 26.2% vs. control, 28.8%, P=0.625). The patients with IBD aged <20 years were at a higher susceptibility risk (nonimmune) for HBV infection than the controls (IBD, 41.5% vs. control, 22.4%; P=0.018). In the multivariate analysis, an age of <20 years (P=0.024) and symptom duration of >= 12 months before diagnosis (P=0.027) were identified as independent risk factors for nonimmunity against HBV infection. Conclusions: The patients newly diagnosed with IBD were susceptible to HBV infection. The frequency of nonimmunity was high, especially in the patients aged <20 years and those with a longer duration of symptoms before diagnosis. Therefore, it is necessary to screen for HBV serologic markers and generate a detailed vaccination plan for patients newly diagnosed with IBD.

引用

页码：400 / 408

页数：9

共 39 条

[1] Regulatory T cells are the most important determinant factor of hepatitis B infection prognosis: A systematic review and meta-analysis [J].