MEDIATION OF RENAL CYST FORMATION BY HEPATOCYTE GROWTH-FACTOR

被引：51

作者：

HORIE, S

HIGASHIHARA, E

NUTAHARA, K

MIKAMI, Y

OKUBO, A

KANO, M

KAWABE, K

机构：

[1] UNIV TOKYO,FAC MED,DEPT LAB MED,TOKYO 113,JAPAN

[2] KYORIN UNIV,FAC MED,DEPT UROL,TOKYO,JAPAN

来源：

LANCET | 1994年 / 344卷 / 8925期

关键词：

D O I：

10.1016/S0140-6736(94)92344-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hepatocyte growth factor (HGF) is a potent mitogen for renal tubular cells, and HGF and its receptor (c-met proto-oncogene product, Met) can induce lumen formation in epithelial cells. We measured the concentration of HGF in cyst fluids from patients with renal cystic diseases. The concentration of HGF was high in proximal cyst fluid (mean 2.45 vs 0.42 ng/mL in distal cysts). Cyclic AMP concentration was higher in distal than in proximal cysts (663 vs 6.0 pmol/L). mRNA of HGF and Met were cc-expressed in cyst walls from cases with polycystic kidney disease. These findings suggest that HGF is a growth factor that may mediate human renal cyst genesis.

引用

页码：789 / 791

页数：3

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