A MAJOR CELLULAR SUBSTRATE FOR PROTEIN-KINASES, ANNEXIN-II, IS A DNA-BINDING PROTEIN

被引：29

作者：

BOYKO, V ^{[1
]}

MUDRAK, O ^{[1
]}

SVETLOVA, M ^{[1
]}

NEGISHI, Y ^{[1
]}

ARIGA, H ^{[1
]}

TOMILIN, N ^{[1
]}

机构：

[1] HOKKAIDO UNIV,FAC PHARMACEUT SCI,SAPPORO 060,JAPAN

来源：

FEBS LETTERS | 1994年 / 345卷 / 2-3期

关键词：

ALU-BINDING PROTEIN; ANNEXIN II; MITOGENIC SIGNAL TRANSDUCTION; PHOSPHOLIPID; CALCIUM ION;

D O I：

10.1016/0014-5793(94)00419-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have screened a human cDNA expression library in lambda gt11 for clones encoding Alu-binding proteins using direct binding of labeled Alu DNA to recombinant phage lysates fixed on a membrane, and isolated a clone 98% identical in sequence to the well-known substrate of protein kinases, annexin II, which was suggested earlier to play a role in transduction of mitogenic signals and DNA replication. A diagnostic property of annexins is their binding to phospholipids in the presence of calcium ions, and we have found that the interaction of proteins of human nuclear extracts with Alu subsequences is suppressed by Ca/phosphatidylserine liposomes, suggesting overlapping of Ca/phospholipid- and DNA-binding domains in annexin II.

引用

页码：139 / 142

页数：4

共 7 条

[1] S-100 PROTEIN BINDS TO ANNEXIN-II AND P11, THE HEAVY AND LIGHT-CHAINS OF CALPACTIN-I
BIANCHI, R
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GIAMBANCO, I
DONATO, R
BIOCHIMICA ET BIOPHYSICA ACTA, 1992, 1160 (01) : 67 - 75
[2] The Npc1 mutation causes an altered expression of caveolin-1, annexin II and protein kinases and phosphorylation of caveolin-1 and annexin II in murine livers
Garver, WS
Hossain, GS
Winscott, MM
Heidenreich, RA
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1999, 1453 (02): : 193 - 206
[3] PHOSPHOLIPID-BINDING PROPERTIES OF CALPHOBINDIN-II(ANNEXIN-VI), AN ANTICOAGULANT PROTEIN FROM HUMAN PLACENTA
YOSHIZAKI, H
HASHIMOTO, Y
ARAI, K
OHKUCHI, M
SHIRATSUCHI, M
SHIDARA, Y
MAKI, M
CHEMICAL & PHARMACEUTICAL BULLETIN, 1991, 39 (10) : 2617 - 2621
[4] Structural elucidation of the protein- and membrane-binding properties of the N-terminal tail domain of human annexin II
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[5] Human epididymis protein 4-annexin II binding promotes aberrant epithelial-fibroblast crosstalk in pulmonary fibrosis
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COMMUNICATIONS BIOLOGY, 2025, 8 (01)
[6] Legumain from bovine kidney: its purification, molecular cloning, immunohistochemical localization and degradation of annexin II and vitamin D-binding protein
Yamane, T
Takeuchi, K
Yamamoto, Y
Li, YH
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Nishi, K
Takahashi, S
Ohkubo, I
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, 2002, 1596 (01): : 108 - 120
[7] 1α,25-dihydroxyvitamin D3 stimulates activator protein 1 DNA-binding activity by a phosphatidylinositol 3-kinase/Ras/MEK/extracellular signal regulated kinase 1/2 and c-Jun N-terminal kinase 1-dependent increase in c-Fos, Fra1, and c-Jun expression in human keratinocytes
Johansen, C
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