THE NITRIC-OXIDE DONORS, AZIDE AND HYDROXYLAMINE, INHIBIT THE PROGRAMMED CELL-DEATH OF CYTOKINE-DEPRIVED HUMAN EOSINOPHILS

被引：116

作者：

BEAUVAIS, F

MICHEL, L

DUBERTRET, L

机构：

[1] INSERM U312, Hôpital Saint-Louis, 75010 Paris, Pavillon Malte, 1, Ave. Claude Vellefaux

来源：

FEBS LETTERS | 1995年 / 361卷 / 2-3期

关键词：

EOSINOPHIL; PROGRAMMED CELL DEATH; APOPTOSIS; NITRIC OXIDE;

D O I：

10.1016/0014-5793(95)00188-F

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Azide and hydroxylamine release nitric oxide (NO) enzymatically in biological conditions, We observed that both compounds were able to inhibit in vitro the programmed cell death of human eosinophils from peripheral blood, This protective effect could be mimicked by permeable cGMP analogs and by the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine. Moreover, the soluble guanylate cyclase inhibitor LY-83583 inhibited in a dose-response manner the effects of the NO donors, Consequently, via the increase of eosinophil survival, NO could contribute to the amplification of inflammatory and allergic processes. This effect appears to be mediated, at least in part, by the soluble guanylate pathway.

引用

页码：229 / 232

页数：4

共 25 条

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