COMBINATION CHEMOTHERAPY WITH EPIRUBICIN, CISPLATIN AND 5-FLUOROURACIL FOR THE PALLIATION OF ADVANCED GASTRIC AND ESOPHAGEAL ADENOCARCINOMA

被引：31

作者：

HIGHLEY, MS ^{[1
]}

PARNIS, FX ^{[1
]}

TROTTER, GA ^{[1
]}

HOUSTON, SJ ^{[1
]}

PENSON, RT ^{[1
]}

HARPER, PG ^{[1
]}

MASON, RC ^{[1
]}

机构：

[1] UNITED MED & DENT SCH,DEPT SURG,LONDON SE1 9RT,ENGLAND

来源：

BRITISH JOURNAL OF SURGERY | 1994年 / 81卷 / 12期

关键词：

D O I：

10.1002/bjs.1800811218

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

The palliative efficacy of laser therapy with combination chemotherapy (cisplatin, epirubicin and continuousinfusion of 5-fluorouracil) was assessed in 34 patients with inoperable gastro-oesophageal cancer. Comparison was made with a group of 30 patients treated previously by aser alone. Twenty patients responded to chemotherapy. There was a significant improvement in dysphagia, as measured by a decreased laser requirement to maintain satisfactory swallowing. In this non-randoized propsective phase II trial, palliation was attained and some responses were long-lasting (median duration of response. 8.7 (range 2.3 to more than 29.2) months).

引用

页码：1763 / 1765

页数：3

共 10 条

[1] VERY LOW-DOSES OF WARFARIN CAN PREVENT THROMBOSIS IN CENTRAL VENOUS CATHETERS - A RANDOMIZED PROSPECTIVE TRIAL [J].

BERN, MM ;

LOKICH, JJ ;

WALLACH, SR ;

BOTHE, A ;

BENOTTI, PN ;

ARKIN, CF ;

GRECO, FA ;

HUBERMAN, M ;

MOORE, C .

ANNALS OF INTERNAL MEDICINE, 1990, 112 (06) :423-428

[2] ESOPHAGEAL CANCER-TREATMENT IN NORTHEAST THAMES REGION, 1981 - MEDICAL AUDIT USING HOSPITAL ACTIVITY ANALYSIS DATA [J].

EARLAM, R .

BRITISH MEDICAL JOURNAL, 1984, 288 (6434) :1892-1894

[3] TREATMENT OF ADENOCARCINOMA OF THE CARDIA WITH SYNCHRONOUS CHEMOTHERAPY AND RADIOTHERAPY [J].

GILL, PG ;

JAMIESON, GG ;

DENHAM, J ;

DEVITT, PG ;

AHMAD, A ;

YEOH, E ;

JONES, AM .

BRITISH JOURNAL OF SURGERY, 1990, 77 (09) :1020-1023

[4] FAMTX VERSUS ETOPOSIDE, DOXORUBICIN, AND CISPLATIN - A RANDOM ASSIGNMENT TRIAL IN GASTRIC-CANCER [J].

KELSEN, D ;

ATIQ, OT ;

SALTZ, L ;

NIEDZWIECKI, D ;

GINN, D ;

CHAPMAN, D ;

HEELAN, R ;

LIGHTDALE, C ;

VINCIGUERRA, V ;

BRENNAN, M .

JOURNAL OF CLINICAL ONCOLOGY, 1992, 10 (04) :541-548

[5] PALLIATION OF MALIGNANT DYSPHAGIA WITH LASER THERAPY - PREDICTABILITY OF RESULTS [J].

MASON, RC ;

BRIGHT, N ;

MCCOLL, I .

BRITISH JOURNAL OF SURGERY, 1991, 78 (11) :1346-1347

[6]

MILLER AB, 1981, CANCER, V47, P207, DOI 10.1002/1097-0142(19810101)47:1<207::AID-CNCR2820470134>3.0.CO

[7]

2-6

[8] SURGICAL THERAPY OF ESOPHAGEAL-CARCINOMA [J].

MULLER, JM ;

ERASMI, H ;

STELZNER, M ;

ZIEREN, U ;

PICHLMAIER, H .

BRITISH JOURNAL OF SURGERY, 1990, 77 (08) :845-857

[9] RADIATION ENHANCEMENT OF LASER PALLIATION FOR MALIGNANT DYSPHAGIA - A PILOT-STUDY [J].

SARGEANT, IR ;

LOIZOU, LA ;

TOBIAS, JS ;

BLACKMAN, G ;

THORPE, S ;

BOWN, SG .

GUT, 1992, 33 (12) :1597-1601

[10] SEQUENTIAL HIGH-DOSE METHOTREXATE AND FLUOROURACIL COMBINED WITH DOXORUBICIN - A STEP AHEAD IN THE TREATMENT OF ADVANCED GASTRIC-CANCER - A TRIAL OF THE EUROPEAN-ORGANIZATION-FOR-RESEARCH-AND-TREATMENT-OF-CANCER GASTROINTESTINAL-TRACT COOPERATIVE GROUP [J].

WILS, JA ;

KLEIN, HO ;

WAGENER, DJT ;

BLEIBERG, H ;

REIS, H ;

KORSTEN, F ;

CONROY, T ;

FICKERS, M ;

LEYVRAZ, S ;

BUYSE, M ;

DUEZ, N .

JOURNAL OF CLINICAL ONCOLOGY, 1991, 9 (05) :827-831

← 1 →