CHEMICAL MODIFICATION OF ERYTHROMYCIN - NOVEL REACTION OBSERVED BY TREATMENT WITH METALLOPORPHYRINS

被引：6

作者：

CELEBUSKI, JE ^{[1
]}

CHORGHADE, MS ^{[1
]}

LEE, EC ^{[1
]}

机构：

[1] ABBOTT LABS,DIV CHEM & AGR PROD,ABBOTT PK,IL 60064

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 23期

关键词：

D O I：

10.1016/S0040-4039(00)76680-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reaction of erythromycin and other macrolides with metalloporphyrins and exogenous cooxidants leads to replacement of the N-dimethyl moiety in the desosamine sugar with complete retention of configuration. The resulting macrolides show antibacterial activity.

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页码：3837 / 3840

页数：4

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