E-CADHERIN AS A TUMOR (INVASION) SUPPRESSOR GENE

被引：166
|
作者：
BIRCHMEIER, W
机构：
[1] Max-Delbrück-Center for Molecular Medicine, Berlin, 13125
来源：
BIOESSAYS | 1995年 / 17卷 / 02期
关键词：
D O I：
10.1002/bies.950170203
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Diffuse-type gastric carcinomas show diminished cell-cell adhesion. A recent paper((1)) reports that 50% of these carcinomas contain mutations in the E-cadherin gene, resulting in the destruction of the calcium-binding sites of E-cadherin, and providing strong in vivo evidence that alterations in E-cadherin play a major role in the development of this particular type of cancer and the short survival of the patients.
引用
收藏
页码：97 / 99
页数：3
相关论文
共 50 条
  • [41] Dual roles of E-cadherin in prostate cancer invasion
    Chunthapong, J
    Seftor, EA
    Khalkhali-Ellis, Z
    Seftor, REB
    Amir, S
    Lubaroff, DM
    Heidger, PM
    Hendrix, MJC
    JOURNAL OF CELLULAR BIOCHEMISTRY, 2004, 91 (04) : 649 - 661
  • [42] Cancer: Context Is Key for E-cadherin in Invasion and Metastasis
    Fearon, Eric R.
    CURRENT BIOLOGY, 2019, 29 (21) : R1140 - R1142
  • [43] E-CADHERIN EXPRESSION - A COUNTERBALANCE FOR CANCER CELL INVASION
    MAREEL, M
    VLEMINCKX, K
    VERMEULEN, S
    BRACKE, M
    VANROY, F
    BULLETIN DU CANCER, 1992, 79 (04) : 347 - 355
  • [44] The association of E-cadherin expression and the methylation status of the E-cadherin gene in nasopharyngeal carcinoma cells
    Tsao, SW
    Liu, Y
    Wang, XH
    Yuen, PW
    Leung, SY
    Yuen, ST
    Pan, J
    Nicholls, JM
    Cheung, ALM
    Wong, YC
    EUROPEAN JOURNAL OF CANCER, 2003, 39 (04) : 524 - 531
  • [45] The MEK2-binding tumor suppressor hDlg is recruited by E-cadherin to the midbody ring
    Suzanne Gaudet
    Marie-Josée Langlois
    Robert A Lue
    Nathalie Rivard
    Alain Viel
    BMC Cell Biology, 12
  • [46] Tumor-suppressor function of Beclin 1 in breast cancer cells requires E-cadherin
    Wijshake, Tobias
    Zou, Zhongju
    Chen, Beibei
    Zhong, Lin
    Xiao, Guanghua
    Xie, Yang
    Doench, John G.
    Bennett, Lynda
    Levine, Beth
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 118 (05)
  • [47] The MEK2-binding tumor suppressor hDlg is recruited by E-cadherin to the midbody ring
    Gaudet, Suzanne
    Langlois, Marie-Josee
    Lue, Robert A.
    Rivard, Nathalie
    Viel, Alain
    BMC CELL BIOLOGY, 2011, 12
  • [48] Expression of E-cadherin and catenins on testis tumor
    Saito, T
    Katagiri, A
    Watanabe, R
    Tanikawa, T
    Kawasaki, T
    Tomita, Y
    Takahashi, K
    UROLOGIA INTERNATIONALIS, 2000, 65 (03) : 140 - 143
  • [49] E-CADHERIN - A BIOLOGICAL MARKER OF TUMOR DIFFERENTIATION
    PIGNATELLI, M
    JOURNAL OF PATHOLOGY, 1993, 171 (02): : 81 - 82
  • [50] DECREASED E-CADHERIN EXPRESSION IN ENDOMETRIAL CARCINOMA IS ASSOCIATED WITH TUMOR DEDIFFERENTIATION AND DEEP MYOMETRIAL INVASION
    SAKURAGI, N
    NISHIYA, M
    IKEDA, K
    OHKOUCH, T
    FURTH, EE
    HAREYAMA, H
    SATOH, C
    FUJIMOTO, S
    GYNECOLOGIC ONCOLOGY, 1994, 53 (02) : 183 - 189
12345