E-CADHERIN AS A TUMOR (INVASION) SUPPRESSOR GENE

被引：166

作者：

BIRCHMEIER, W

机构：

[1] Max-Delbrück-Center for Molecular Medicine, Berlin, 13125

来源：

BIOESSAYS | 1995年 / 17卷 / 02期

关键词：

D O I：

10.1002/bies.950170203

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Diffuse-type gastric carcinomas show diminished cell-cell adhesion. A recent paper((1)) reports that 50% of these carcinomas contain mutations in the E-cadherin gene, resulting in the destruction of the calcium-binding sites of E-cadherin, and providing strong in vivo evidence that alterations in E-cadherin play a major role in the development of this particular type of cancer and the short survival of the patients.

引用

页码：97 / 99

页数：3

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