E-CADHERIN AS A TUMOR (INVASION) SUPPRESSOR GENE

被引：166
作者：
BIRCHMEIER, W
机构：
[1] Max-Delbrück-Center for Molecular Medicine, Berlin, 13125
来源：
BIOESSAYS | 1995年 / 17卷 / 02期
关键词：
D O I：
10.1002/bies.950170203
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Diffuse-type gastric carcinomas show diminished cell-cell adhesion. A recent paper((1)) reports that 50% of these carcinomas contain mutations in the E-cadherin gene, resulting in the destruction of the calcium-binding sites of E-cadherin, and providing strong in vivo evidence that alterations in E-cadherin play a major role in the development of this particular type of cancer and the short survival of the patients.
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页码：97 / 99
页数：3
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共 36 条
  • [11] GAMALLO C, 1993, AM J PATHOL, V142, P987
  • [12] Desmosomes and hemidesmosomes
    Garrod, David R.
    [J]. CURRENT OPINION IN CELL BIOLOGY, 1993, 5 (01) : 30 - 40
  • [13] THE UVOMORULIN-ANCHORAGE PROTEIN ALPHA-CATENIN IS A VINCULIN HOMOLOG
    HERRENKNECHT, K
    OZAWA, M
    ECKERSKORN, C
    LOTTSPEICH, F
    LENTER, M
    KEMLER, R
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (20) : 9156 - 9160
  • [14] DYNAMICS OF CADHERIN/CATENIN COMPLEX-FORMATION - NOVEL PROTEIN INTERACTIONS AND PATHWAYS OF COMPLEX ASSEMBLY
    HINCK, L
    NATHKE, IS
    PAPKOFF, J
    NELSON, WJ
    [J]. JOURNAL OF CELL BIOLOGY, 1994, 125 (06) : 1327 - 1340
  • [15] IDENTIFICATION OF A NEURAL ALPHA-CATENIN AS A KEY REGULATOR OF CADHERIN FUNCTION AND MULTICELLULAR ORGANIZATION
    HIRANO, S
    KIMOTO, N
    SHIMOYAMA, Y
    HIROHASHI, S
    TAKEICHI, M
    [J]. CELL, 1992, 70 (02) : 293 - 301
  • [16] HULSKEN J, 1994, IN PRESS J CELL BIOL
  • [17] REGULATION OF EMBRYONIC-CELL ADHESION BY THE CADHERIN CYTOPLASMIC DOMAIN
    KINTNER, C
    [J]. CELL, 1992, 69 (02) : 225 - 236
  • [18] PLAKOGLOBIN, OR AN 83-KD HOMOLOG DISTINCT FROM BETA-CATENIN, INTERACTS WITH E-CADHERIN AND N-CADHERIN
    KNUDSEN, KA
    WHEELOCK, MJ
    [J]. JOURNAL OF CELL BIOLOGY, 1992, 118 (03) : 671 - 679
  • [19] MAYER B, 1993, CANCER RES, V53, P1690
  • [20] A HOMOLOG OF THE ARMADILLO PROTEIN IN DROSOPHILA (PLAKOGLOBIN) ASSOCIATED WITH E-CADHERIN
    MCCREA, PD
    TURCK, CW
    GUMBINER, B
    [J]. SCIENCE, 1991, 254 (5036) : 1359 - 1361
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