E-CADHERIN AS A TUMOR (INVASION) SUPPRESSOR GENE

被引：166
作者：
BIRCHMEIER, W
机构：
[1] Max-Delbrück-Center for Molecular Medicine, Berlin, 13125
来源：
BIOESSAYS | 1995年 / 17卷 / 02期
关键词：
D O I：
10.1002/bies.950170203
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Diffuse-type gastric carcinomas show diminished cell-cell adhesion. A recent paper((1)) reports that 50% of these carcinomas contain mutations in the E-cadherin gene, resulting in the destruction of the calcium-binding sites of E-cadherin, and providing strong in vivo evidence that alterations in E-cadherin play a major role in the development of this particular type of cancer and the short survival of the patients.
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页码：97 / 99
页数：3
相关论文
共 36 条
[11]  
GAMALLO C, 1993, AM J PATHOL, V142, P987
[12]   Desmosomes and hemidesmosomes [J].
Garrod, David R. .
CURRENT OPINION IN CELL BIOLOGY, 1993, 5 (01) :30-40
[13]   THE UVOMORULIN-ANCHORAGE PROTEIN ALPHA-CATENIN IS A VINCULIN HOMOLOG [J].
HERRENKNECHT, K ;
OZAWA, M ;
ECKERSKORN, C ;
LOTTSPEICH, F ;
LENTER, M ;
KEMLER, R .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (20) :9156-9160
[14]   DYNAMICS OF CADHERIN/CATENIN COMPLEX-FORMATION - NOVEL PROTEIN INTERACTIONS AND PATHWAYS OF COMPLEX ASSEMBLY [J].
HINCK, L ;
NATHKE, IS ;
PAPKOFF, J ;
NELSON, WJ .
JOURNAL OF CELL BIOLOGY, 1994, 125 (06) :1327-1340
[15]   IDENTIFICATION OF A NEURAL ALPHA-CATENIN AS A KEY REGULATOR OF CADHERIN FUNCTION AND MULTICELLULAR ORGANIZATION [J].
HIRANO, S ;
KIMOTO, N ;
SHIMOYAMA, Y ;
HIROHASHI, S ;
TAKEICHI, M .
CELL, 1992, 70 (02) :293-301
[16]  
HULSKEN J, 1994, IN PRESS J CELL BIOL
[17]   REGULATION OF EMBRYONIC-CELL ADHESION BY THE CADHERIN CYTOPLASMIC DOMAIN [J].
KINTNER, C .
CELL, 1992, 69 (02) :225-236
[18]   PLAKOGLOBIN, OR AN 83-KD HOMOLOG DISTINCT FROM BETA-CATENIN, INTERACTS WITH E-CADHERIN AND N-CADHERIN [J].
KNUDSEN, KA ;
WHEELOCK, MJ .
JOURNAL OF CELL BIOLOGY, 1992, 118 (03) :671-679
[19]  
MAYER B, 1993, CANCER RES, V53, P1690
[20]   A HOMOLOG OF THE ARMADILLO PROTEIN IN DROSOPHILA (PLAKOGLOBIN) ASSOCIATED WITH E-CADHERIN [J].
MCCREA, PD ;
TURCK, CW ;
GUMBINER, B .
SCIENCE, 1991, 254 (5036) :1359-1361
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