E-CADHERIN AS A TUMOR (INVASION) SUPPRESSOR GENE

被引：166
作者：
BIRCHMEIER, W
机构：
[1] Max-Delbrück-Center for Molecular Medicine, Berlin, 13125
来源：
BIOESSAYS | 1995年 / 17卷 / 02期
关键词：
D O I：
10.1002/bies.950170203
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Diffuse-type gastric carcinomas show diminished cell-cell adhesion. A recent paper((1)) reports that 50% of these carcinomas contain mutations in the E-cadherin gene, resulting in the destruction of the calcium-binding sites of E-cadherin, and providing strong in vivo evidence that alterations in E-cadherin play a major role in the development of this particular type of cancer and the short survival of the patients.
引用
收藏
页码：97 / 99
页数：3
相关论文
共 36 条
[1]  
BECKER KF, 1994, CANCER RES, V54, P3845
[2]   DISSECTING TUMOR-CELL INVASION - EPITHELIAL-CELLS ACQUIRE INVASIVE PROPERTIES AFTER THE LOSS OF UVOMORULIN-MEDIATED CELL CELL-ADHESION [J].
BEHRENS, J ;
MAREEL, MM ;
VANROY, FM ;
BIRCHMEIER, W .
JOURNAL OF CELL BIOLOGY, 1989, 108 (06) :2435-2447
[3]   CADHERIN EXPRESSION IN CARCINOMAS - ROLE IN THE FORMATION OF CELL-JUNCTIONS AND THE PREVENTION OF INVASIVENESS [J].
BIRCHMEIER, W ;
BEHRENS, J .
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 1994, 1198 (01) :11-26
[4]   CELL-ADHESION MOLECULE UVOMORULIN IS LOCALIZED IN THE INTERMEDIATE JUNCTIONS OF ADULT INTESTINAL EPITHELIAL-CELLS [J].
BOLLER, K ;
VESTWEBER, D ;
KEMLER, R .
JOURNAL OF CELL BIOLOGY, 1985, 100 (01) :327-332
[5]   PLAKOGLOBIN AND BETA-CATENIN - DISTINCT BUT CLOSELY RELATED [J].
BUTZ, S ;
STAPPERT, J ;
WEISSIG, H ;
KEMLER, R .
SCIENCE, 1992, 257 (5073) :1142-1144
[6]  
DORUDI S, 1993, AM J PATHOL, V142, P981
[7]   A GENETIC MODEL FOR COLORECTAL TUMORIGENESIS [J].
FEARON, ER ;
VOGELSTEIN, B .
CELL, 1990, 61 (05) :759-767
[8]   MOLECULAR-CLONING AND AMINO-ACID SEQUENCE OF HUMAN PLAKOGLOBIN, THE COMMON JUNCTIONAL PLAQUE PROTEIN [J].
FRANKE, WW ;
GOLDSCHMIDT, MD ;
ZIMBELMANN, R ;
MUELLER, HM ;
SCHILLER, DL ;
COWIN, P .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (11) :4027-4031
[9]   E-CADHERIN-MEDIATED CELL CELL-ADHESION PREVENTS INVASIVENESS OF HUMAN CARCINOMA-CELLS [J].
FRIXEN, UH ;
BEHRENS, J ;
SACHS, M ;
EBERLE, G ;
VOSS, B ;
WARDA, A ;
LOCHNER, D ;
BIRCHMEIER, W .
JOURNAL OF CELL BIOLOGY, 1991, 113 (01) :173-185
[10]   TUMOR DEDIFFERENTIATION - AN IMPORTANT STEP IN TUMOR INVASION [J].
GABBERT, H ;
WAGNER, R ;
MOLL, R ;
GERHARZ, CD .
CLINICAL & EXPERIMENTAL METASTASIS, 1985, 3 (04) :257-279
1234