IN-VIVO NITROSATION OF METAMIZOLE IN MAN

被引：3
|
作者：
ZIEBARTH, D
机构：
[1] Centrum für Molekulare Medizin, Berlin, 13125
来源：
ARCHIV DER PHARMAZIE | 1994年 / 327卷 / 06期
关键词：
D O I：
10.1002/ardp.19943270607
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Monitoring the excretion of the non-carcinogenic nitroso-methylaminoan-tipyrine (NMAA) after peroral applications of the analgesic drug metamizole is a useful procedure for evaluating endogenous nitrosation, also in man. The outstanding nitrosatibility of this drug led to high amounts of excreted NMAA, easily detected without derivatisation by HPLC. By nitrate ingestion considered as normal dietary intake the nitrosation is scarcely modified by ascorbic acid, sodium-bicarbonate or sodium-bicarbonate plus metronidazole. These results are an other indication of a third, cell-mediated path of endogeneous nitrosation in man.
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页码：381 / 384
页数：4
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