CURED MULTIPLE-MYELOMA FOLLOWED BY PRIMARY MALIGNANT-LYMPHOMA OF THE LUNG

被引：0
作者：
SCHATTNER, A
NISSIM, F
BERREBI, A
机构：
[1] Departments of Medicine 'A' Kaplan Hospital, Rehovot affiliated to the Hebrew University and Hadassah Medical School Jerusalem
[2] Pathology, Kaplan Hospital, Rehovot affiliated to the Hebrew University and Hadassah Medical School Jerusalem
[3] Hematology, Kaplan Hospital, Rehovot affiliated to the Hebrew University and Hadassah Medical School Jerusalem
来源：
LEUKEMIA & LYMPHOMA | 1991年 / 5卷 / 5-6期
关键词：
MULTIPLE MYELOMA; MALIGNANT LYMPHOMA; EXTRANODAL LYMPHOMA;
D O I：
10.3109/10428199109067641
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A 56-year-old patient was found to have smouldering myeloma which remained asymptomatic and untreated for 13 years. Localised osteolytic lesions then appeared, which responded to local irradiation. Six years later, an increased serum M-protein became evident (IgG$LD, 3 gr/dl) associated with 35% plasma cells in the bone marrow, which necessitated melphalan/prednisone therapy. A prolonged complete remission was achieved lasting 6 years. Thereafter, the patient developed a myelodysplastic syndrome with leukopenia and refractory anemia and he finally died of pulmonary disease. Autopsy revealed extensive thoracic involvement by a primary malignant lymphoma of the lungs (IgMK) with no evidence of myeloma. Such a long follow-up with subsequent cure is rare in multiple myeloma as is the appearance of a second B cell malignancy, which may either be associated with the myeloma and/or chemotherapy given, or a coincidental occurrence. © 1991 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
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页码：441 / 445
页数：5
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