HIGHLY ENANTIOSELECTIVE ROUTES TO DARZENS AND ACETATE ALDOL PRODUCTS FROM ACHIRAL ALDEHYDES AND TERT-BUTYL BROMOACETATE

被引：81

作者：

COREY, EJ

CHOI, SY

机构：

[1] Department of Chemistry, Harvard University, Cambridge

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 25期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0040-4039(91)80631-F

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New methodology is described for the enantioselective coupling of t-butyl bromoacetate with aldehydes to give anti-alpha-bromo beta-hydroxy esters (1), useful precursors of chiral glycidic esters (2), acetate aldols (3), beta-amino acid esters (4) and alpha-amino acid esters (5).

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页码：2857 / 2860

页数：4

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