THE SEQUENCE OF 5' FLANKING DNA FROM THE RAT PREPROTACHYKININ GENE - ANALYSIS OF PUTATIVE TRANSCRIPTION FACTOR BINDING-SITES

被引：6
|
作者：
CHAPMAN, K [1 ]
LYONS, V [1 ]
HARMAR, AJ [1 ]
机构：
[1] ROYAL EDINBURGH & ASSOCIATED HOSP,MRC,BRAIN METAB UNIT,EDINBURGH,SCOTLAND
来源：
BIOCHIMICA ET BIOPHYSICA ACTA | 1993年 / 1172卷 / 03期
关键词：
PREPROTACHYKININ GENE; 5' FLANKING SEQUENCE; PUTATIVE TRANSCRIPTION FACTOR BINDING SITE; (RAT);
D O I：
10.1016/0167-4781(93)90233-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The rat preprotachykinin A (rPPT-A) gene is expressed in restricted populations of neurons and endocrine cells, including a subset of dorsal root ganglion (DRG) neurons. As part of a study to investigate the DNA sequences responsible for tissue-specific expression of the gene, we have determined the sequence of the 5' flanking DNA to 3350 bp upstream of the transcription start site. The sequenced region encodes a number of putative transcription factor binding sites which may play important roles in the regulation of rPPT-A gene transcription.
引用
收藏
页码：361 / 363
页数：3
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