AMPHETAMINE LOWERS EXTRACELLULAR GABA CONCENTRATION IN THE VENTRAL PALLIDUM

被引：63

作者：

BOURDELAIS, A

KALIVAS, PW

机构：

[1] Department of Veterinary Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman

来源：

BRAIN RESEARCH | 1990年 / 516卷 / 01期

关键词：

Amphetamine; Dialysis; Dopamine; Motor activity; Ventral pallidum; γ-Aminobutyric acid;

D O I：

10.1016/0006-8993(90)90907-S

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In vivo dialysis was performed in the ventral pallidum of the conscious rat, and extracellular levels of γ-aminobutyric acid (GABA) measured. Forty minutes following peripheral administration of amphetamine (2.0 mg/kg, s.c.) the extracellular concentration of GABA was significantly reduced, in parallel with a significant elevation in motor activity. These data indicate that a decline in GABA transmission in the ventral pallidum may be important in the initiation of amphetamine-induced motor activity. © 1990.

引用

页码：132 / 136

页数：5

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