Impact of type of donor on graft and patient survival rate in kidney transplanted patients in Iran

Introduction: End-stage renal disease (ESRD(is an increasing problem in the world. Kidney transplant is considered as preferred therapeutic method for ESRD. Options for organ transplantation include living related donor (LRD), living unrelated donor (LURD) and cadaveric donor. Objectives: This study was aimed to evaluate the effect of type of donor on graft and survival rate of patients. Patients and Methods: This study was cross-sectional, which used Meier method to calculate the patient survival rate. Additionally log-rank test was applied to compare the survival curves; analysis of variance (ANOVA) was applied to compare continuous variables and chi(2) test was used to compare the data. Data were analyzed using SPSS version 19 and P values less than 0.05 was considered significant. Results: The mean duration of follow-up in LRD, LURD and cadaveric recipients were 60.37 +/- 34.2, 79.17 +/- 33 and 61.17 +/- 34 months respectively. Five-year survival, in LRD was 100 months, in LURD recipients was 87 +/- 0.01 months, and in cadaveric recipients was 91 +/- 0.03 months. The mean survival of graft in LRD, LURD and cadaveric recipients were 115.5 +/- 3.1, 103.27 +/- 1.2 and 102.15 +/- 4.5 months, respectively. Log-rank test showed a significant difference between graft survival in recipients (P = 0.038). Conclusion: The results showed that LRD is one of the factors affecting graft survival. Hence, graft survival rate showed high length among patients who their graft was from LRD compared to LURD and cadaveric.