PROPERTIES AND ANTI-HIV ACTIVITY OF CIRCULAR SENSE AND ANTISENSE OLIGONUCLEOTIDES

被引：5
|
作者：
YAMAKAWA, H
ISHIBASHI, T
NAKASHIMA, H
YAMAMOTO, N
TAKAI, K
TAKAKU, H
机构：
[1] CHIBA INST TECHNOL,DEPT IND CHEM,NARASHINO,CHIBA 275,JAPAN
[2] RAT DRUG DESIGN LABS,FUKUSHIMA 96012,JAPAN
[3] YAMANASHI MED UNIV,DEPT MICROBIOL,YAMANASHI 40938,JAPAN
[4] TOKYO MED & DENT UNIV,SCH MED,DEPT MICROBIOL,BUNKYO KU,TOKYO 113,JAPAN
来源：
NUCLEOSIDES & NUCLEOTIDES | 1995年 / 14卷 / 3-5期
关键词：
D O I：
10.1080/15257779508012551
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The circularization of a 48 mer oligonucleotide was investigated by using enzymatic ligation with T4 DNA ligase. This method yielded 30% circular molecules. The circular oligonucleotides are molecules with no free ends and are therefore more resistant to exonuclease attack. The circular oligonucleotide has remarkably increased Tm values as compared to the nicked and double stranded DNAs. However, the RNase H activity is lower than that with a single stranded DNA. We also describe the anti-HIV activity of a circular oligonucleotide.
引用
收藏
页码：1149 / 1152
页数：4
相关论文
共 50 条
  • [21] Synthesis and anti-HIV activity of arylpiperazinyl fluoroquinolones: A new class of anti-HIV agents
    Hagihara, M
    Kashiwase, H
    Katsube, T
    Kimura, T
    Komai, T
    Momota, K
    Ohmine, T
    Nishigaki, T
    Kimura, S
    Shimada, K
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1999, 9 (21) : 3063 - 3068
  • [22] Characterizing the Anti-HIV Activity of Papuamide A
    Andjelic, Cynthia D.
    Planelles, Vicente
    Barrows, Louis R.
    MARINE DRUGS, 2008, 6 (04): : 528 - 549
  • [23] Pentafuside: Shows anti-HIV activity
    不详
    AIDS PATIENT CARE AND STDS, 1996, 10 (03) : 184 - 184
  • [24] SYNTHETIC PTEROCARPANS WITH ANTI-HIV ACTIVITY
    ENGLER, TA
    LYNCH, KO
    REDDY, JP
    GREGORY, GS
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1993, 3 (06) : 1229 - 1232
  • [25] Anti-HIV Activity of LXR Agonists
    Grant, Angela M.
    Morrow, Matthew P.
    Dubrovsky, Larisa
    Kashanchi, Fatah
    Sviridov, Dmitri
    Bukrinsky, Michael
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2009, 29 (07) : E73 - E73
  • [26] SYNTHESIS AND ANTI-HIV ACTIVITY OF ISONUCLEOSIDES
    HURYN, DM
    SLUBOSKI, BC
    TAM, SY
    WEIGELE, M
    SIM, I
    ANDERSON, BD
    MITSUYA, H
    BRODER, S
    JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (13) : 2347 - 2354
  • [27] STUDY OF ANTI-HIV ACTIVITY OF MYRAMISTIN
    KRIVORUTCHENKO, YL
    KRIVOSHEIN, YS
    MARENNIKOVA, SS
    STEPANOVA, LG
    NOSIK, DN
    KALNINA, LB
    RUDKO, AP
    VOPROSY VIRUSOLOGII, 1994, 39 (06) : 267 - 269
  • [28] ANTI-HIV ACTIVITY OF SULFATED POLYSACCHARIDES
    DECLERCQ, E
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1992, 204 : 8 - CARB
  • [29] Sulfone derivatives with anti-HIV activity
    Silvestri, R
    Artico, M
    Massa, S
    Stefancich, G
    Congeddu, E
    Putzolu, M
    LaColla, P
    FARMACO, 1997, 52 (05): : 323 - 329
  • [30] TERPENES WITH ANTI-HIV BIOLOGICAL ACTIVITY
    Macias Villamizar, Victor Enrique
    Alvarez Caballero, Juan Manuel
    Suarez Gomez, Hernando
    DUAZARY, 2010, 7 (02) : 257 - 273
12345