URIC-ACID NEPHROLITHIASIS

被引:0
|
作者
HALABE, A
SPERLING, O
机构
[1] BEILINSON MED CTR, DEPT METAB, IL-49100 PETAH TIQWA, ISRAEL
[2] TEL AVIV UNIV, SACKLER FAC MED, IL-69978 TEL AVIV, ISRAEL
关键词
GOUT; NEPHROLITHIASIS; PURINE NUCLEOTIDE METABOLISM; URIC ACID; URIC ACID LITHIASIS;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Uric acid is the end-product of purine nucleotide metabolism in man. The renal handling of urate is a complicated process, resulting in a fractional clearance of 8.2 - 10.3%, The anhydrous form is thermodynamically the most stable uric acid crystal. Uric acid is a weak acid that ionizes with a Pka at pH 5.75. At the normal acidic region, uric acid solubilty is strongly increased by urinary pH. The prevalence of uric acid stones varies between countries, reflecting climatic, dietary, and ethnical differences, ranging from 2.1% (in Texas) to 37.7% (in Iran). The risk for uric acid stone formation correlates with the degree of uric acid supersaturation in the urine, depending on uric acid concentration and urinary pH. Hyperuricosuria is the major risk factor, the most common cause being increased purine intake in the diet, Acquired and hereditary diseases accompanied by hyperuricosuria and stone disease include: gout, in strong correlation with the amount of uric acid excreted, myelo- and lymphoproliferative disorders, multiple myeloma, secondary polycythemia, pernicious anemia and hemolytic disorders, hemoglobinopathies and thalassemia, the complete or partial deficiency of HGPRT, superactivity of PRPP synthetase, and hereditary renal hypouricemia. A common denominator in patients with idiopathic and gouty stone formers is a low urinary pH. Uric acid nephrolithiasis is indicated in the presence of a radiolucent stone, a persistent undue urine acidity and uric acid crystals in fresh urine samples. A radiolucent stone in combination with normal or acidic pH should raise the possibility of urate stones. Uric acid stones can be effectively treated and prevented by increasing the solubility of urinary uric acid. This is obtained by increasing urine volume, by augmenting urinary pH and by decreasing uric acid production (by decreasing dietary purine intake and by pharmacological inhibition of uric acid formation by allopurinol).
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页码:424 / 431
页数:8
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