IMMUNOREACTIVE C-TYPE NATRIURETIC PEPTIDE IN HUMAN ADRENAL-GLANDS AND ADRENAL-TUMORS

被引：15

作者：

TOTSUNE, K ^{[1
]}

TAKAHASHI, K ^{[1
]}

MURAKAMI, O ^{[1
]}

ITOI, K ^{[1
]}

SONE, M ^{[1
]}

OHNEDA, M ^{[1
]}

SATOH, F ^{[1
]}

MIURA, Y ^{[1
]}

MOURI, T ^{[1
]}

机构：

[1] TOHOKU UNIV, SCH MED, DEPT PATHOL 2, SENDAI, MIYAGI 980, JAPAN

来源：

PEPTIDES | 1994年 / 15卷 / 02期

关键词：

C-TYPE NATRIURETIC PEPTIDE; RADIOIMMUNOASSAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; GEL CHROMATOGRAPHY; PHEOCHROMOCYTOMA; PRIMARY ALDOSTERONISM; ADRENAL GLAND;

D O I：

10.1016/0196-9781(94)90014-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

C-type natriuretic peptide (CNP) in human adrenal glands and adrenal tumors was measured with a specific radioimmunoassay for CNP. Tissue immunoreactive (IR-) CNP concentrations were 0.54 +/- 0.40 pmol/g wet tissue (gwt) (mean +/- SD) in 14 pheochromocytomas, 0.69 +/- 0.19 pmol/gwt in six adrenocortical tumors, and 0.49 +/- 0.22 pmol/gwt in seven normal adrenal glands (cortex and medulla mixed). These concentrations were comparable to those found in tissues from human brains. Sephadex G-50 superfine column chromatography and reverse-phase high performance liquid chromatography revealed that IR-CNP in normal adrenal glands and pheochromocytoma consisted of at least two components: a component in low molecular weight form chromatographically identical to CNP-22 and the other, a high molecular weight form very similar to human CNP-53. This study has shown that IR-CNP is present in human adrenal glands and adrenal tumors with similar molecular forms and comparable concentrations to those in the human brain.

引用

页码：287 / 290

页数：4

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