ANTIVIRAL ACTIVITY OF PRIMATE GAMMA-DELTA T-LYMPHOCYTES ISOLATED BY MAGNETIC CELL SORTING

被引：17
作者：
WALLACE, M
GAN, YH
PAUZA, CD
MALKOVSKY, M
机构：
[1] UNIV WISCONSIN,SCH MED,DEPT MED MICROBIOL & IMMUNOL,1300 UNIV AVE,MADISON,WI 53706
[2] UNIV WISCONSIN,SCH MED,DEPT PATHOL,MADISON,WI 53706
[3] UNIV WISCONSIN,SCH MED,DEPT HUMAN ONCOL,MADISON,WI 53706
[4] WISCONSIN REG PRIMATE RES CTR,MADISON,WI
来源：
JOURNAL OF MEDICAL PRIMATOLOGY | 1994年 / 23卷 / 2-3期
关键词：
GAMMA-DELTA-T-CELLS; IL-2; STIMULATION; CYTOTOXICITY; IMMUNODEFICIENCY VIRUSES;
D O I：
10.1111/j.1600-0684.1994.tb00113.x
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
The exposure of human or rhesus monkey peripheral blood mononuclear cells (PBMCs) to interleukin 2 (IL-2) in vitro resulted in a selective outgrowth of gammadelta lymphocytes. Using positive selection by monoclonal antibodies and magnetic beads, gammadelta T lymphocytes were isolated from these cultures. Without priming by viral antigens, the purified gammadelta T lymphocytes lyse immunodeficiency virus-infected cells substantially better than the uninfected counterparts.
引用
收藏
页码：131 / 135
页数：5
相关论文
共 22 条
  • [1] MOLECULAR-CLONING OF LYMPHADENOPATHY-ASSOCIATED VIRUS
    ALIZON, M
    SONIGO, P
    BARRESINOUSSI, F
    CHERMANN, JC
    TIOLLAIS, P
    MONTAGNIER, L
    WAINHOBSON, S
    [J]. NATURE, 1984, 312 (5996) : 757 - 760
  • [2] DIFFERENTIAL GROWTH REQUIREMENTS AND EFFECTOR FUNCTIONS OF ALPHA-BETA AND GAMMA-DELTA HUMAN T-CELLS
    APARICIO, P
    ALONSO, JM
    TORIBIO, ML
    GUTIERREZ, JC
    PEZZI, L
    MARTINEZ, C
    [J]. IMMUNOLOGICAL REVIEWS, 1989, 111 : 5 - 33
  • [3] AUTRAN B, 1989, CLIN EXP IMMUNOL, V75, P206
  • [4] IMMUNOCHEMICAL PROOF THAT A NOVEL REARRANGING GENE ENCODES THE T-CELL RECEPTOR-DELTA SUBUNIT
    BAND, H
    HOCHSTENBACH, F
    MCLEAN, J
    HATA, S
    KRANGEL, MS
    BRENNER, MB
    [J]. SCIENCE, 1987, 238 (4827) : 682 - 684
  • [5] SELECTIVE INCREASE OF A SUBSET OF T-CELL RECEPTOR GAMMA-DELTA LYMPHOCYTES-T IN THE PERIPHERAL-BLOOD OF PATIENTS WITH HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION
    DEMARIA, A
    FERRAZIN, A
    FERRINI, S
    CICCONE, E
    TERRAGNA, A
    MORETTA, L
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1992, 165 (05) : 917 - 919
  • [6] DEPAOLI P, 1991, CLIN EXP IMMUNOL, V83, P187, DOI 10.1111/j.1365-2249.1991.tb05612.x
  • [7] GAMMA-DELTA-T-CELL CLONES AND NATURAL-KILLER-CELL CLONES MEDIATE DISTINCT PATTERNS OF NONMAJOR HISTOCOMPATIBILITY COMPLEX-RESTRICTED CYTOLYSIS
    FISCH, P
    MALKOVSKY, M
    BRAAKMAN, E
    STURM, E
    BOLHUIS, RLH
    PRIEVE, A
    SOSMAN, JA
    LAM, VA
    SONDEL, PM
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 171 (05) : 1567 - 1579
  • [8] RECOGNITION BY HUMAN V-GAMMA-9/V-DELTA-2 T-CELLS OF A GROEL HOMOLOG ON DAUDI-BURKITT LYMPHOMA-CELLS
    FISCH, P
    MALKOVSKY, M
    KOVATS, S
    STURM, E
    BRAAKMAN, E
    KLEIN, BS
    VOSS, SD
    MORRISSEY, LW
    DEMARS, R
    WELCH, WJ
    BOLHUIS, RLH
    SONDEL, PM
    [J]. SCIENCE, 1990, 250 (4985) : 1269 - 1273
  • [9] FOLEY GE, 1965, CANCER, V18, P522, DOI 10.1002/1097-0142(196504)18:4<522::AID-CNCR2820180418>3.0.CO
  • [10] 2-J
123