HISTAMINE STIMULATES EXOCYTOSIS IN A SUBPOPULATION OF BOVINE ADRENAL CHROMAFFIN CELLS

被引:10
作者
PENDER, N
BURGOYNE, RD
机构
[1] UNIV LIVERPOOL,PHYSIOL LAB,POB 147,LIVERPOOL L69 3BX,ENGLAND
[2] UNIV LIVERPOOL,DENT SCI CLIN,LIVERPOOL L69 3BX,ENGLAND
基金
英国惠康基金;
关键词
CHROMAFFIN CELL; HISTAMINE; SECRETION; EXOCYTOSIS; CALCIUM;
D O I
10.1016/0304-3940(92)90751-R
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Both nicotinic stimulation and histamine are able to raise cytosolic free calcium concentration in the majority of cells in a population of bovine adrenal medullary chromaffin cells to comparable levels. Nevertheless, histamine induces much less catecholamine secretion than does nicotine. In order to test whether this is due to heterogeneity in the responses of chromaffin cells to histamine we examined exocytosis in response to nicotine and histamine using an immunofluorescence method based on staining with anti-DBH to detect inserted secretory vesicle membrane. The results show that while up to 98% of the chromaffin cells in culture undergo exocytosis in response to nicotine, histamine stimulates exocytosis in only a sub-population of cells.
引用
收藏
页码:207 / 210
页数:4
相关论文
共 16 条
[1]   A MAJOR ROLE FOR PROTEIN KINASE-C IN CALCIUM-ACTIVATED EXOCYTOSIS IN PERMEABILISED ADRENAL CHROMAFFIN CELLS [J].
BURGOYNE, RD ;
MORGAN, A ;
OSULLIVAN, AJ .
FEBS LETTERS, 1988, 238 (01) :151-155
[2]   CONTROL OF EXOCYTOSIS IN ADRENAL CHROMAFFIN CELLS [J].
BURGOYNE, RD .
BIOCHIMICA ET BIOPHYSICA ACTA, 1991, 1071 (02) :174-202
[3]   CHANGES IN INOSITOL 1,4,5-TRISPHOSPHATE AND INOSITOL 1,3,4,5-TETRAKISPHOSPHATE MASS ACCUMULATIONS IN CULTURED ADRENAL CHROMAFFIN CELLS IN RESPONSE TO BRADYKININ AND HISTAMINE [J].
CHALLISS, RAJ ;
JONES, JA ;
OWEN, PJ ;
BOARDER, MR .
JOURNAL OF NEUROCHEMISTRY, 1991, 56 (03) :1083-1086
[4]   SPATIAL LOCALIZATION OF THE STIMULUS-INDUCED RISE IN CYTOSOLIC CA-2+ IN BOVINE ADRENAL CHROMAFFIN CELLS - DISTINCT NICOTINIC AND MUSCARINIC PATTERNS [J].
CHEEK, TR ;
OSULLIVAN, AJ ;
MORETON, RB ;
BERRIDGE, MJ ;
BURGOYNE, RD .
FEBS LETTERS, 1989, 247 (02) :429-434
[5]   SIMULTANEOUS MEASUREMENTS OF CYTOSOLIC CALCIUM AND SECRETION IN SINGLE BOVINE ADRENAL CHROMAFFIN CELLS BY FLUORESCENT IMAGING OF FURA-2 IN COCULTURED CELLS [J].
CHEEK, TR ;
JACKSON, TR ;
OSULLIVAN, AJ ;
MORETON, RB ;
BERRIDGE, MJ ;
BURGOYNE, RD .
JOURNAL OF CELL BIOLOGY, 1989, 109 (03) :1219-1227
[6]  
GREENBERG A, 1982, CELL TISSUE RES, V226, P655
[8]   HISTAMINE-INDUCED INCREASES IN CYCLIC-AMP LEVELS IN BOVINE ADRENAL-MEDULLARY CELLS [J].
MARLEY, PD ;
THOMSON, KA ;
JACHNO, K ;
JOHNSTON, MJ .
BRITISH JOURNAL OF PHARMACOLOGY, 1991, 104 (04) :839-846
[9]   H-1-HISTAMINERGIC ACTIVATION OF CATECHOLAMINE RELEASE BY CHROMAFFIN CELLS [J].
NOBLE, EP ;
BOMMER, M ;
LIEBISCH, D ;
HERZ, A .
BIOCHEMICAL PHARMACOLOGY, 1988, 37 (02) :221-228
[10]   LOCALIZATION AND HETEROGENEITY OF AGONIST-INDUCED CHANGES IN CYTOSOLIC CALCIUM-CONCENTRATION IN SINGLE BOVINE ADRENAL CHROMAFFIN CELLS FROM VIDEO IMAGING OF FURA-2 [J].
OSULLIVAN, AJ ;
CHEEK, TR ;
MORETON, RB ;
BERRIDGE, MJ ;
BURGOYNE, RD .
EMBO JOURNAL, 1989, 8 (02) :401-411