SAFETY AND IMMUNOGENICITY OF A BOOSTER DOSE OF VIBRIO-CHOLERAE CVD-103-HGR LIVE ORAL CHOLERA VACCINE IN SWISS ADULTS

被引：25

作者：

CRYZ, SJ ^{[1
]}

LEVINE, MM ^{[1
]}

LOSONSKY, G ^{[1
]}

KAPER, JB ^{[1
]}

ALTHAUS, B ^{[1
]}

机构：

[1] UNIV MARYLAND,SCH MED,CTR VACCINE DEV,BALTIMORE,MD 21201

来源：

INFECTION AND IMMUNITY | 1992年 / 60卷 / 09期

关键词：

D O I：

10.1128/IAI.60.9.3916-3917.1992

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Adult volunteers received a booster dose (4 x 10(8) CFU) of attenuated Vibrio cholerae CVD 103-HgR oral vaccine 15 or 24 months after primary immunization. The immune response was modest, presumably due to rapid clearance of the vaccine strain by a primed immune system.

引用

页码：3916 / 3917

页数：2

共 7 条

[1]

BENENSON AS, 1968, B WORLD HEALTH ORGAN, V38, P277

[2] RANDOMIZED DOUBLE-BLIND PLACEBO CONTROLLED TRIAL TO EVALUATE THE SAFETY AND IMMUNOGENICITY OF THE LIVE ORAL CHOLERA VACCINE STRAIN CVD-103-HGR IN SWISS ADULTS [J].

CRYZ, SJ ;

LEVINE, MM ;

KAPER, JB ;

FURER, E ;

ALTHAUS, B .

VACCINE, 1990, 8 (06) :577-580

[3] RECOMBINANT ATTENUATED VIBRIO-CHOLERAE STRAINS USED AS LIVE ORAL VACCINES [J].

KAPER, JB ;

LEVINE, MM .

RESEARCH IN MICROBIOLOGY, 1990, 141 (7-8) :901-906

[4]

LEVINE M M, 1988, Lancet, V2, P467

[5] ENZYME-LINKED IMMUNOSORBENT-ASSAY TO MEASURE ANTIBODIES TO PURIFIED HEAT-LABILE ENTEROTOXINS FROM HUMAN AND PORCINE STRAINS OF ESCHERICHIA-COLI AND TO CHOLERA-TOXIN - APPLICATION IN SERODIAGNOSIS AND SEROEPIDEMIOLOGY [J].

LEVINE, MM ;

YOUNG, CR ;

BLACK, RE ;

TAKEDA, Y ;

FINKELSTEIN, RA .

JOURNAL OF CLINICAL MICROBIOLOGY, 1985, 21 (02) :174-179

[6] PRELIMINARY ASSESSMENT OF THE SAFETY AND IMMUNOGENICITY OF LIVE ORAL CHOLERA VACCINE STRAIN CVD 103-HGR IN HEALTHY THAI ADULTS [J].

MIGASENA, S ;

PITISUTTITHAM, P ;

PRAYURAHONG, B ;

SUNTHARASAMAI, P ;

SUPANARANOND, W ;

DESAKORN, V ;

VONGSTHONGSRI, U ;

TALL, B ;

KETLEY, J ;

LOSONSKY, G ;

CRYZ, S ;

KAPER, JB ;

LEVINE, MM .

INFECTION AND IMMUNITY, 1989, 57 (11) :3261-3264

[7]

SUAREHAWARATANA P, IN PRESS J INFECT DI

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