Low-dose rivaroxaban plus aspirin for the prevention of cardiovascular events: an evaluation of COMPASS

被引：5

作者：

Bhagirath, Vinai C. ^{[1
,2
]}

Eikelboom, John W. ^{[1
,2
]}

Anand, Sonia S. ^{[1
,2
]}

机构：

[1] McMaster Univ, Dept Med, Hamilton, ON L8S 4K1, Canada

[2] Populat Hlth Res Inst, Hamilton, ON L8L 2X2, Canada

来源：

FUTURE CARDIOLOGY | 2018年 / 14卷 / 06期

关键词：

aspirin; cardiovascular disease; rivaroxaban;

D O I：

10.2217/fca-2018-0059

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The cardiovascular outcomes for people using anticoagulation strategies (NCT01776424) trial randomized 27,395 patients with stable coronary artery disease or peripheral artery disease (PAD) to receive rivaroxaban 5 mg twice-daily alone, the combination of rivaroxaban 2.5 mg twice-daily and aspirin 100 mg daily, or aspirin 100 mg daily alone. The combination arm resulted in a 24% reduction in the primary end point of cardiovascular death, stroke or myocardial infarction, and an 18% reduction in mortality. Rivaroxaban alone did not produce any additional benefit compared with aspirin. The combination therapy also reduced major adverse limb events, including amputation, in patients with PAD. Based on these results, the addition of rivaroxaban to aspirin is expected to substantially reduce morbidity and mortality in patients with stable coronary or PAD.

引用

页码：443 / 454

页数：12

共 22 条

[1]

Anand S, 2007, NEW ENGL J MED, V357, P217

[2] Rivaroxaban with or without aspirin in patients with stable peripheral or carotid artery disease: an international, randomised, double-blind, placebo-controlled trial [J].

Anand, Sonia S. ;

Bosch, Jackie ;

Eikelboom, John W. ;

Connolly, Stuart J. ;

Diaz, Rafael ;

Widimsky, Peter ;

Aboyans, Victor ;

Alings, Marco ;

Kakkar, Ajay K. ;

Keltai, Katalin ;

Maggioni, Aldo P. ;

Lewis, Basil S. ;

Stoerk, Stefan ;

Zhu, Jun ;

Lopez-Jaramillo, Patricio ;

O'Donnell, Martin ;

Commerford, Patrick J. ;

Vinereanu, Dragos ;

Pogosova, Nana ;

Ryden, Lars ;

Fox, Keith A. A. ;

Bhatt, Deepak L. ;

Misselwitz, Frank ;

Varigos, John D. ;

Vanassche, Thomas ;

Avezum, Alvaro A. ;

Chen, Edmond ;

Branch, Kelley ;

Leong, Darryl P. ;

Bangdiwala, Shrikant I. ;

Hart, Robert G. ;

Yusuf, Salim .

LANCET, 2018, 391 (10117) :219-229

[3] Patients with prior myocardial infarction, stroke, or symptomatic peripheral arterial disease in the CHARISMA trial [J].

Bhatt, Deepak L. ;

Flather, Marcus D. ;

Hacke, Werner ;

Berger, Peter B. ;

Black, Henry R. ;

Boden, William E. ;

Cacoub, Patrice ;

Cohen, Eric A. ;

Creager, Mark A. ;

Easton, J. Donald ;

Hamm, Christian W. ;

Hankey, Graeme J. ;

Johnston, S. Claiborne ;

Mak, Koon-Hou ;

Mas, Jean-Louis ;

Montalescot, Gilles ;

Pearson, Thomas A. ;

Steg, P. Gabriel ;

Steinhubl, Steven R. ;

Weber, Michael A. ;

Fabry-Ribaudo, Liz ;

Hu, Tingfei ;

Topol, Eric J. ;

Fox, A. A. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2007, 49 (19) :1982-1988

[4] Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events [J].

Bhatt, DL ;

Fox, KAA ;

Hacke, W ;

Berger, PB ;

Black, HR ;

Boden, WE ;

Cacoub, P ;

Cohen, EA ;

Creager, MA ;

Easton, JD ;

Flather, MD ;

Haffner, SM ;

Hamm, CW ;

Hankey, GJ ;

Johnston, SC ;

Mak, KH ;

Mas, JL ;

Montalescot, G ;

Pearson, TA ;

Steg, PG ;

Steinhubl, SR ;

Weber, MA ;

Brennan, DM ;

Fabry-Ribaudo, L ;

Booth, J ;

Topol, EJ ;

Frye, RL ;

Amarenco, P ;

Brass, LM ;

Buyse, M ;

Cohen, LS ;

DeMets, DL ;

Fuster, V ;

Hart, RG ;

Marler, JR ;

McCarthy, C ;

Schoemig, A ;

Lincoff, AM ;

Brener, SJ ;

Sila, CA ;

Albuquerque, A ;

Aroutiounov, G ;

Artemiev, D ;

Atkeson, BG ;

Bartel, T ;

Basart, DCG ;

Lima, AB ;

Belli, G ;

Bordalo e Sa, AL ;

Bosch, X .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (16) :1706-1717

[5] Ticagrelor for Prevention of Ischemic Events After Myocardial Infarction in Patients With Peripheral Artery Disease [J].

Bonaca, Marc P. ;

Bhatt, Deepak L. ;

Storey, Robert F. ;

Steg, Gabriel ;

Cohen, Marc ;

Kuder, Julia ;

Goodrich, Erica ;

Nicolau, Jose C. ;

Parkhomenko, Alexander ;

Lopez-Sendon, Jose ;

Dellborg, Mikael ;

Dalby, Anthony ;

Spinar, Jindrich ;

Aylward, Philip ;

Corbalan, Ramon ;

Abola, Maria Teresa B. ;

Jensen, Eva C. ;

Held, Peter ;

Braunwald, Eugene ;

Sabatine, Marc S. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2016, 67 (23) :2719-2728

[6] Acute Limb Ischemia and Outcomes With Vorapaxar in Patients With Peripheral Artery Disease Results From the Trial to Assess the Effects of Vorapaxar in Preventing Heart Attack and Stroke in Patients With Atherosclerosis-Thrombolysis in Myocardial Infarction 50 (TRA2°P-TIMI 50) [J].

Bonaca, Marc P. ;

Gutierrez, J. Antonio ;

Creager, Mark A. ;

Scirica, Benjamin M. ;

Olin, Jeffrey ;

Murphy, Sabina A. ;

Braunwald, Eugene ;

Morrow, David A. .

CIRCULATION, 2016, 133 (10) :997-1005

[7] Long-Term Use of Ticagrelor in Patients with Prior Myocardial Infarction [J].

Bonaca, Marc P. ;

Bhatt, Deepak L. ;

Cohen, Marc ;

Steg, Philippe Gabriel ;

Storey, Robert F. ;

Jensen, Eva C. ;

Magnani, Giulia ;

Bansilal, Sameer ;

Fish, M. Polly ;

Im, Kyungah ;

Bengtsson, Olof ;

Ophuis, Ton Oude ;

Budaj, Andrzej ;

Theroux, Pierre ;

Ruda, Mikhail ;

Hamm, Christian ;

Goto, Shinya ;

Spinar, Jindrich ;

Nicolau, Jose Carlos ;

Kiss, Robert G. ;

Murphy, Sabina A. ;

Wiviott, Stephen D. ;

Held, Peter ;

Braunwald, Eugene ;

Sabatine, Marc S. ;

Morin, Suzanne ;

Dantzer, Emily ;

Acquilano, Dayle ;

McGuire, Rachael L. ;

Gannon, Joseph B. ;

Gershman, Elaine ;

Ahlbom, Ann Maxe ;

Boberg, Barbro ;

Abola, Maria Teresa ;

Ardissino, Diego ;

Aylward, Philip ;

Corbalan, Ramon ;

Dalby, Anthony ;

Diaz, Rafael ;

Hu, Dayi ;

Isaza, Daniel ;

Kamensky, Gabriel ;

Kiss, Robert ;

Kontny, Frederic ;

Lopez-Sendon, Jose ;

Medina, Felix ;

Montalescot, Gilles ;

Nicolau, Jose ;

Paolasso, Ernesto ;

Parkhomenko, Alexander .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 372 (19) :1791-1800

[8] Vorapaxar in Patients With Peripheral Artery Disease Results From TRA2°P-TIMI 50 [J].

Bonaca, Marc P. ;

Scirica, Benjamin M. ;

Creager, Mark A. ;

Olin, Jeffrey ;

Bounameaux, Henri ;

Dellborg, Mikael ;

Lamp, Jessica M. ;

Murphy, Sabina A. ;

Braunwald, Eugene ;

Morrow, David A. .

CIRCULATION, 2013, 127 (14) :1522-+

[9]

Collins R, 2009, LANCET, V373, P1849, DOI 10.1016/S0140-6736(09)60503-1

[10] Rivaroxaban with or without aspirin in patients with stable coronary artery disease: an international, randomised, double-blind, placebo-controlled trial [J].

Connolly, Stuart J. ;

Eikelboom, John W. ;

Bosch, Jackie ;

Dagenais, Gilles ;

Dyal, Leanne ;

Lanas, Fernando ;

Metsarinne, Kaj ;

O'Donnell, Martin ;

Dans, Anthony L. ;

Ha, Jong-Won ;

Parkhomenko, Alexandr N. ;

Avezum, Alvaro A. ;

Lonn, Eva ;

Liu Lisheng ;

Torp-Pedersen, Christian ;

Widimsky, Petr ;

Maggioni, Aldo P. ;

Felix, Camilo ;

Keltai, Katalin ;

Hori, Masatsugu ;

Yusoff, Khalid ;

Guzik, Tomasz J. ;

Bhatt, Deepak L. ;

Branch, Kelley R. H. ;

Bruns, Nancy Cook ;

Berkowitz, Scott D. ;

Anand, Sonia S. ;

Varigos, John D. ;

Fox, Keith A. A. ;

Yusuf, Salim .

LANCET, 2018, 391 (10117) :205-218

← 1 2 3 →