STRAIGHTFORWARD SYNTHESIS OF 1,2,3-TRICARBONYL SYSTEMS

被引：27

作者：

LINDE, RG ^{[1
]}

JERONCIC, LO ^{[1
]}

DANISHEFSKY, SJ ^{[1
]}

机构：

[1] YALE UNIV,DEPT CHEM,NEW HAVEN,CT 06511

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1991年 / 56卷 / 07期

关键词：

D O I：

10.1021/jo00007a049

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple two-step protocol for the preparation of alpha,beta-diketo amides is described. The first step involves condensation of the anion of an alpha-phenylthio amide with an aldehyde. This is followed by oxidation of the resulting beta-hydroxy alpha-sulfide with the Dess-Martin periodinane. The vicinal tricarbonyl system is obtained in good to excellent yields.

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页码：2534 / 2538

页数：5

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