Scientific Opinion on the substantiation of a health claim related to olive (Olea europaea L.) leaf water extract and increase in glucose tolerance pursuant to Article 13(5) of Regulation (EC) No 1924/2006

被引:0
作者
Agostoni, Carlo [1 ]
Canani, Roberto Berni [1 ]
Fairweather-Tait, Susan [1 ]
Heinonen, Marina [1 ]
Korhonen, Hannu [1 ]
La Vieille, Sebastien [1 ]
Marchelli, Rosangela [1 ]
Martin, Ambroise [1 ]
Naska, Androniki [1 ]
Neuhaeuser-Berthold, Monika [1 ]
Nowicka, Grazyna [1 ]
Sanz, Yolanda [1 ]
Siani, Alfonso [1 ]
Sjoedin, Anders [1 ]
Stern, Martin [1 ]
Strain, Sean [1 ]
Tetens, Inge [1 ]
Tome, Daniel [1 ]
Turck, Dominique [1 ]
Verhagen, Hans [1 ]
机构
[1] EFSA, Parma, Italy
关键词
olive leaf water extract; oleuropein; glucose tolerance; health claim;
D O I
10.2903/j.efsa.2014.3655
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Following an application from Comvita New Zealand Limited, submitted pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of the United Kingdom, the Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on the scientific substantiation of a health claim related to olive (Olea europaea L.) leaf water extract and increase in glucose tolerance. The food that is the subject of the health claim, olive leaf water extract standardised by its content of oleuropein, is sufficiently characterised. The claimed effect, an increase in glucose tolerance, is a beneficial physiological effect as long as serum insulin concentrations are not disproportionately increased. One human intervention study showed an increase in glucose tolerance without disproportionate increase in insulin concentrations after daily consumption of the olive leaf water extract for 12 weeks under the conditions of use proposed by the applicant. However, the results have not been replicated in other studies, and no evidence has been provided in relation to the mechanism by which the olive leaf water extract could exert the claimed effect. The scientific evidence is insufficient to establish a cause and effect relationship between the consumption of olive leaf water extract and an increase in glucose tolerance. (C) European Food Safety Authority, 2014
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页数:10
相关论文
共 16 条
[1]   Antioxidant activity of phenolics extracted from Olea europaea L-leaves [J].
Benavente-García, O ;
Castillo, J ;
Lorente, J ;
Ortuño, A ;
Del Rio, JA .
FOOD CHEMISTRY, 2000, 68 (04) :457-462
[2]   Olive (Olea europaea L.) Leaf Polyphenols Improve Insulin Sensitivity in Middle-Aged Overweight Men: A Randomized, Placebo-Controlled, Crossover Trial [J].
de Bock, Martin ;
Derraik, Jose G. B. ;
Brennan, Christine M. ;
Biggs, Janene B. ;
Morgan, Philip E. ;
Hodgkinson, Steven C. ;
Hofman, Paul L. ;
Cutfield, Wayne S. .
PLOS ONE, 2013, 8 (03)
[3]  
Department of Noncommunicable Disease Surveillance, 1999, DEF DIAGN CLASS DI 1
[4]   Role of interleukin-6 signalling in glucose and lipid metabolism [J].
Glund, S. ;
Krook, A. .
ACTA PHYSIOLOGICA, 2008, 192 (01) :37-48
[5]   HYPOGLYCEMIC ACTIVITY OF OLIVE LEAF [J].
GONZALEZ, M ;
ZARZUELO, A ;
GAMEZ, MJ ;
UTRILLA, MP ;
JIMENEZ, J ;
OSUNA, I .
PLANTA MEDICA, 1992, 58 (06) :513-515
[6]   Antidiabetic and Antioxidant Effects of Hydroxytyrosol and Oleuropein from Olive Leaves in Alloxan-Diabetic Rats [J].
Jemai, Hedya ;
El Feki, Abdelfattah ;
Sayadi, Sami .
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2009, 57 (19) :8798-8804
[7]   INTERLEUKIN-6 AND INSULIN RESISTANCE [J].
Kim, Jeong-Ho ;
Bachmann, Rebecca A. ;
Chen, Jie .
VITAMINS AND HORMONES INSULIN AND IGFS, 2009, 80 :613-633
[8]   Identification of anti-α-amylase components from olive leaf extracts [J].
Komaki, E ;
Yamaguchi, S ;
Maru, I ;
Kinoshita, M ;
Kakehi, K ;
Ohta, Y ;
Tsukada, Y .
FOOD SCIENCE AND TECHNOLOGY RESEARCH, 2003, 9 (01) :35-39
[9]  
Lockyer S., 2012, NUTR AGING, V1, P125, DOI [10.3233/NUA-2012-0011, DOI 10.3233/NUA-2012-0011]
[10]  
de Castro MDL, 2010, OLIVES AND OLIVE OIL IN HEALTH AND DISEASE PREVENTION, P259, DOI 10.1016/B978-0-12-374420-3.00028-0