THE ANTIMICROBIAL ACTIVITY OF HEXAPEPTIDES DERIVED FROM SYNTHETIC COMBINATORIAL LIBRARIES

被引：83
作者：
BLONDELLE, SE
TAKAHASHI, E
DINH, KT
HOUGHTEN, RA
机构：
[1] Torrey Pines Institute for Molecular Studies, San Diego, California
来源：
JOURNAL OF APPLIED BACTERIOLOGY | 1995年 / 78卷 / 01期
关键词：
D O I：
10.1111/j.1365-2672.1995.tb01671.x
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
A series of peptides identified through the use of synthetic hexapeptide combinatorial libraries (represented by the formula Ac-RRWWCO-NH2) were examined for their antimicrobial activity against five different micro-organisms. Their toxicity was also evaluated in an in vitro haemolytic assay. The peptides showed activity against the five micro-organisms, although higher activities were found against Gram-positive bacteria. Both growth inhibition and cell viability assays were carried out to demonstrate the bactericidal activities of these peptides against two of the micro-organisms tested. The dimeric cystine forms of these peptides were shown to have biological activities identical to the monomeric forms.
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页码：39 / 46
页数：8
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